Effect of Intravenous 5% Dextrose Infusion During Recovery from Anesthesia on the Quality of Early Postoperative Recovery in Patients Undergoing Painless Gastrointestinal Endoscopy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Preoperative blood glucose 30min
研究概览
简要总结
The aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who meet the indications for painless gastrointestinal endoscopy and are aged 18 to 79 years.
- •The patient or his/her guardian or immediate family members gave informed consent;
- •American Society of Anesthesiology (ASA) anesthesia risk classification ≤ grade III.
排除标准
- •Patients with contraindications to sedation/anesthesia for gastrointestinal endoscopy: e.g., severe hepatic and renal dysfunction, cardiac insufficiency;
- •Patients receiving chemotherapy and opioid treatment; patients with a history of sleep apnea hypoventilation syndrome;
- •Intravenous nutritional support within 8 hours prior to the examination;
- •Patients diagnosed with type I or type II diabetes.
研究组 & 干预措施
Experimental group
Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.
干预措施: 5% glucose (Other)
结局指标
主要结局
Preoperative blood glucose 30min
时间窗: Measurements taken 0.5 hours Preoperative.
A fingertip blood glucose concentration of \<3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 0.5 hours Preoperative.
Postoperative blood glucose 2h
时间窗: Measured at 2 hours postoperatively.
A fingertip blood glucose concentration of \<3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 2 hours postoperatively.
Dizziness level
时间窗: Measured at 0.5 hours postoperatively.
The visual analogue scale (VAS) was used to assess the degree of postoperative dizziness in patients undergoing painless gastroenteroscopy.
Postoperative nausea and vomiting
时间窗: Measured at 2 hours postoperatively.
The Index of Nausea and Vomiting and Retching (INVR) was used in this study. The scale consists of 8 items with 3 dimensions, which can quantify the number of occurrences, duration and severity of symptoms. The scale is scored using the Likert method, with a total of 32 points on a 5-point scale ranging from 0 to 4. The higher the score, the more severe the symptoms of nausea, vomiting, and dry heaving (entries 1, 6, and 7 are reverse scored). According to the score, nausea, vomiting and dry heaving symptoms can be categorized into five grades: 0, I, II, III and IV, and grade ≥I means that the symptom occurs. The severity and incidence of PONV at 0.5 hours postoperatively.
次要结局
- Anesthesia awakening time(Approximately 30min after surgery)
- Quality of postoperative recovery (QoR40)(Approximately 24hours after surgery)
研究者
Lin Cheng
Research investigator
Weifang Medical University