Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex

Not Applicable

Not yet recruiting

• Conditions: Extubation; Sugammadex; Smooth Emergence
• Interventions: Drug: sugammadex

• Registration Number: NCT05751603
• Lead Sponsor: Ajou University School of Medicine

Brief Summary

After surgery is completed under general anesthesia, extubation is performed after recovery from anesthesia, and during this process, bucking, coughing, and rapid and excessive hemodynamic fluctuations occur very often. These phenomena can lead to high intrathoracic pressure, venous congestion, hematoma formation, or increased bleeding after major neck surgery. (1) They can also increase the risk of aerosol generation, which can transmit infection to health care workers. (2) For this, smooth extubation is required. Methods of administering drugs such as lidocaine, opioids, or dexmedetomidine have been proposed for smooth extubation. (3-5) As a disadvantage, the use of these drugs may be associated with deep sedation and reduced airway reflexes .

Recently, Babu et al. (6) reported that bucking and coughing during extubation could be reduced by changing the timing of administering a muscle relaxant antagonist rather than using these sedative drugs, and thus complications related to extubation could be reduced. In general, in the awakening process, it was common to administer the muscle relaxant at the point of recovery of spontaneous breathing. However, Babu et al. demonstrated the possibility of safe and smooth extubation by changing the timing of administering neostigmine without the use of sedatives or narcotic analgesics, but there are few studies on sugammadex.

Therefore, when recovering from general anesthesia, sugammadex was administered before and immediately after extubation to evaluate and compare smooth extubation (ie, comparison of the frequency of bucking and coughing).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-02-21
• Study First Submitted QC: 2023-02-21
• Study First Posted: 2023-03-02
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-23
• Last Update Posted: 2024-07-25
• Study Start: 2024-10-03
• Primary Completion: 2025-10-03
• Study Completion: 2025-10-03

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• patients undergoing general anesthesia for thyroid surgery.
• aged between 19 and 64 years
• American Society of Anesthesiologists physical status I and II

Exclusion Criteria

• patients with malformation or tumor of the upper respiratory tract
• patients with risk of aspiration
• obese cases with a BMI > 35
• patients in which tracheal intubation was difficult
• refusal to participate in research

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental group	sugammadex	sugammadex is administered just after extubation.

Primary Outcome Measures

Name	Time	Method
extubation quality score	immediate after extubation	score based on the incidence and severity of coughing straining

Secondary Outcome Measures

Name	Time	Method
time to extubation	immediate after extubation	time from withdrawal of anesthetics to extubation
time to respiration	immediate after extubation	time from withdrawal of anesthetics to respiration
sore throat in postanesthetic care unit	in postanesthetic care unit	Scores obtained by questioning the patient in postanesthetic care unit