Effect of Cerebral Blood Flow on Cognition Across Healthy Adulthood

Jim Cotter0 sites28 target enrollmentSeptember 27, 2018

Overview

Phase: 未知
Intervention: Not specified
Conditions: Not specified
Sponsor: Jim Cotter
Enrollment: 28
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

At baseline, older adults had lower cognitive performance and CBF, but similar cerebrovascular reactivity to CO2 and dynamic cerebral autoregulation compared to young adults. In both young and older adults, cognitive performance on a mental switching task was slightly (7%) reduced after indomethacin, but not significantly associated with reductions in CBF (~31%). These results indicate that cognitive performance is broadly resilient against a ~31% reduction in CBF per se in healthy young and older adults.

Registry

who.int

Start Date

September 27, 2018

End Date

February 4, 2019

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Investigators

Sponsor

Jim Cotter

Eligibility Criteria

Inclusion Criteria

•No signs of cognitive impairment and non\-smoker.

Exclusion Criteria

•Currently taking, or required to take any medication listed below:
•oCardiac glycosides
•oAminoglycosides
•oAnticoagulants
•oAntihypertensive
•oNon\-steroidal anti\-inflammatories
•oCorticosteroids
•Known cardiovascular, cerebrovascular, neurological, metabolic, respiratory, renal, or haematological disease or condition.
•Allergic to NSAIDs.