ACTRN12618001603202已完成未知
Effect of Cerebral Blood Flow on Cognition Across Healthy Adulthood
Jim Cotter0 个研究点目标入组 28 人开始时间: 2018年9月27日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 28
研究概览
简要总结
At baseline, older adults had lower cognitive performance and CBF, but similar cerebrovascular reactivity to CO2 and dynamic cerebral autoregulation compared to young adults. In both young and older adults, cognitive performance on a mental switching task was slightly (7%) reduced after indomethacin, but not significantly associated with reductions in CBF (~31%). These results indicate that cognitive performance is broadly resilient against a ~31% reduction in CBF per se in healthy young and older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •No signs of cognitive impairment and non-smoker.
排除标准
- •Currently taking, or required to take any medication listed below:
- •oCardiac glycosides
- •oAminoglycosides
- •oAnticoagulants
- •oAntihypertensive
- •oNon-steroidal anti-inflammatories
- •oCorticosteroids
- •Known cardiovascular, cerebrovascular, neurological, metabolic, respiratory, renal, or haematological disease or condition.
- •Allergic to NSAIDs.
研究者
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