The Influence and Potential Mechanism of Cardiovascular Risk Factors on the Cognitive Trajectories Among Cognitively Intact Older Adults
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Peking University Sixth Hospital
- Enrollment
- 3372
- Locations
- 1
- Primary Endpoint
- Regression coefficients
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The cognitive trajectory varies among non-demented older adults. In a 12-year follow-up study, we found approximately 5% participants presented rapid cognitive decline. Cardiovascular diseases increased the risk of cognitive decline. However, the influence of cardiovascular risk factors on cognitive decline remained inconsistent. Besides, the potential mechanism of the cardiovascular risk factors and cognitive function has not been fully investigated. Therefore, the proposed program will include two sub-studies. The first sub-study will use the longitudinal data from the Chinese Longitudinal Healthy Longevity Survey to evaluate the influence of cardiovascular risk factors on the trajectories of cognitive function. The second sub-study will recruit cognitive intact older adults with different levels of cardiovascular risk factors. The association among cardiovascular risk factors, cerebral blood flow, brain functional connectivity and cognitive function will be investigated with structural equation modeling. The findings of the proposed program will provide novel insight on preventing cognitive decline from the angle of maintaining healthy vascular function, and will provide evidence in elucidating the potential neurovascular mechanism between cardiovascular risk factors and cognitive function.
Investigators
Xiaozhen LV
Associate Researcher
Peking University Sixth Hospital
Eligibility Criteria
Inclusion Criteria
- •Aged 65 or over at baseline;
- •With normal cognitive function at baseline (score ≥ 18 on the Chinese version of Mini-Mental State Examination, MMSE);
- •Had at least one domain information about cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity, exercise, diet and smoking) at baseline;
- •Completed cognitive function assessment at least twice during 3 waves following-up after baseline;
- •Provided informed consent voluntarily.
Exclusion Criteria
- •had a history of dementia or MMSE score \< 18 at baseline;
- •Without more than once cognitive function assessment during the follow-up;
- •Refused to participate the survey.
- •For the neuroimaging sample, who would be enrolled by this study:
- •Inclusion Criteria:
- •Aged 55-80;
- •Right-handed;
- •Primary school education or above, with normal communication ability;
- •No complaints of cognitive impairment or decline;
- •MMSE score ≥ 26;
Outcomes
Primary Outcomes
Regression coefficients
Time Frame: up to 10 years
the influence of cardiovascular risk factors on cognitive change
Secondary Outcomes
- the correlation coefficient(baseline)