Obstetric Outcomes of Women Suffering From Hereditary Fibrinogen Disorders
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypofibrinogenemia, Congenital
- Sponsor
- University Hospital, Geneva
- Enrollment
- 149
- Locations
- 3
- Primary Endpoint
- Prevalence of normal issue pregnancy
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia) as well as to describe pregnancies outcomes in such diseases.
Detailed Description
Women with quantitative or qualitative fibrinogen disorders are often more prone to obstetrical complications, from bleeding to recurrent miscarriages or thrombosis. Data on fibrinogen levels variations throughout the pregnancy and on the delivery management are lacking. In this observational study will be include adult women with pas obstetrical history. A general questionnaire on demographics and clinical data will be filled out by the patient's physician. A detailed questionnaire on obstetrical data will also be completed contacting the patient in case of lacking data.
Investigators
Casini Alessandro
MD, Principal Investigator
University Hospital, Geneva
Eligibility Criteria
Inclusion Criteria
- •Inherited fibrinogen disorders (hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia)
- •At lest one past pregnancy
Exclusion Criteria
- •No past pregnancy
- •Not confirmed fibrinogen disorder
Outcomes
Primary Outcomes
Prevalence of normal issue pregnancy
Time Frame: At inclusion
All pregnancy not resulting in miscarriage, stillbirth or abortion
Secondary Outcomes
- Prevalence of pregnancy without complications(At inclusion)
- Post-partum complications(At inclusion)
- Modalities of delivery(At inclusion)
- Fibrinogen variations(At inclusion)