Obstetric Outcomes of Women Suffering From Hereditary Fibrinogen Disorders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 149
- 试验地点
- 3
- 主要终点
- Prevalence of normal issue pregnancy
研究概览
简要总结
The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia) as well as to describe pregnancies outcomes in such diseases.
详细描述
Women with quantitative or qualitative fibrinogen disorders are often more prone to obstetrical complications, from bleeding to recurrent miscarriages or thrombosis. Data on fibrinogen levels variations throughout the pregnancy and on the delivery management are lacking. In this observational study will be include adult women with pas obstetrical history. A general questionnaire on demographics and clinical data will be filled out by the patient's physician. A detailed questionnaire on obstetrical data will also be completed contacting the patient in case of lacking data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Inherited fibrinogen disorders (hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia)
- •At lest one past pregnancy
排除标准
- •No past pregnancy
- •Not confirmed fibrinogen disorder
结局指标
主要结局
Prevalence of normal issue pregnancy
时间窗: At inclusion
All pregnancy not resulting in miscarriage, stillbirth or abortion
次要结局
- Prevalence of pregnancy without complications(At inclusion)
- Post-partum complications(At inclusion)
- Modalities of delivery(At inclusion)
- Fibrinogen variations(At inclusion)
研究者
Casini Alessandro
MD, Principal Investigator
University Hospital, Geneva