Effect of a Mixed Macronutritional Meal With Medium Chain Triglycerides on the Oxidation of Postprandial Macronutrients
- Conditions
- Metabolic Syndrome
- Interventions
- Dietary Supplement: Mixed meal with medium chain triglyceridesDietary Supplement: Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides
- Registration Number
- NCT04321018
- Lead Sponsor
- Universidad de Granada
- Brief Summary
The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e. fat oxidation, carbohydrate oxidation, change in respiratory quotient, peak respiratory quotient, etc.).
- Detailed Description
A mixed meal characterized by a high quantity of carbohydrates could develop an increment in the postprandial carbohydrate oxidation. Medium chain triglycerides could be absorbed and metabolized immediately. It is plausible that its addition to a mixed meal unchains the decrement in the carbohydrate oxidation and increment in fat oxidation. If this hypothesis it is correct, its lower postprandial carbohydrate oxidation could develop a higher postprandial exposure to hyperglycemia, being of clinical interest.
20 young adults will be randomized into two conditions (experimental and control conditions) with 7 days of separation between conditions. Each evaluation day will conform to the following tests:
1. Basal metabolic rate assessment through indirect calorimetry.
2. Intake of the corresponding mixed meal (experimental or control)
3. Postprandial nutrient oxidation and energy expenditure through indirect calorimetry
4. Blood samples assessment in 9 time points during the evaluation day.
5. Post-prandial sensations related to appetite in 11 time points during the evaluation day
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Healthy male or female
- Ages 18-30 years
- BMI: 18-27.5 kg/m2
- Stable weight over the last 3 months (body weight changes<35kg)
- Participant must be capable and willing to provide consent, understand exclusion criteria, instructions and protocols.
- History of cardiovascular disease
- Diabetes or hypertension
- Pregnant, planning to become pregnant, or breastfeeding
- Have been treated previously or during the study period with prescription drugs: antihypertensive, lipid lowering, acid uric lowering, glucose lowering, beta blockers or any drug that under the investigator's judged could influence the results.
- Hematological pathology
- Have had a blood transfusion or severe blood loss within the last 3 months
- Allergy/intolerance to milk proteins, fish, soy, and/or any ingredient of the mixed meal
- Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
- Claustrophobia
- Needle phobia
- Are deemed unsuitable by the investigator for any other reason, that prevent data collection.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Meal with medium chain triglycerdies first Mixed meal with medium chain triglycerides Arm 1: participants randomized to receive the mixed meal with medium chain triglycerides first. Meal with medium chain triglycerdies second Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides Arm 2: participants randomized to receive the mixed meal without medium chain triglycerides first.te Meal with medium chain triglycerdies first Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides Arm 1: participants randomized to receive the mixed meal with medium chain triglycerides first. Meal with medium chain triglycerdies second Mixed meal with medium chain triglycerides Arm 2: participants randomized to receive the mixed meal without medium chain triglycerides first.te
- Primary Outcome Measures
Name Time Method Post-prandial nutrient oxidation 4 hours Fat or carbohydrate oxidation measured by indrect calorimetry
- Secondary Outcome Measures
Name Time Method Post-prandial blood non-esterified fatty acid concentrations 4 hours Measures of blood non-esterified fatty acid concentrations
Post-prandial blood tryglicerides concentrations 4 hours Measures of blood tryglicerides concentrations
Post-prandial blood glycerol concentrations 4 hours Measures of blood glycerol concentrations
Post-prandial energy expenditure 4 hours Measured by indrect calorimetry
Post-prandial sensations related to appetite 4 hours Measured by visual analogue scales (VAS). Score ranging from 0 to 100mm. Higher values mean the most positive rating, while lower values mean the most negative rating.
Post-prandial blood insulin concentrations 4 hours Measures of blood insulin concentrations
Post-prandial blood cholesterol concentrations 4 hours Measures of blood cholesterol concentrations
Post-prandial blood lactate concentrations 4 hours Measures of blood lactate concentrations
Post-prandial blood glucose concentrations 4 hours Measures of blood glucose concentrations
Trial Locations
- Locations (1)
Jonatan Ruiz Ruiz
🇪🇸Granada, Spain