Effect of the Addition of Medium Chain Triglycerides to a Mixed Macronutritional Meal on the Oxidation of Postprandial Macronutrients
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Universidad de Granada
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- Post-prandial nutrient oxidation
Study Overview
Brief Summary
The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e. fat oxidation, carbohydrate oxidation, change in respiratory quotient, peak respiratory quotient, etc.).
Detailed Description
A mixed meal characterized by a high quantity of carbohydrates could develop an increment in the postprandial carbohydrate oxidation. Medium chain triglycerides could be absorbed and metabolized immediately. It is plausible that its addition to a mixed meal unchains the decrement in the carbohydrate oxidation and increment in fat oxidation. If this hypothesis it is correct, its lower postprandial carbohydrate oxidation could develop a higher postprandial exposure to hyperglycemia, being of clinical interest.
20 young adults will be randomized into two conditions (experimental and control conditions) with 7 days of separation between conditions. Each evaluation day will conform to the following tests:
- Basal metabolic rate assessment through indirect calorimetry.
- Intake of the corresponding mixed meal (experimental or control)
- Postprandial nutrient oxidation and energy expenditure through indirect calorimetry
- Blood samples assessment in 9 time points during the evaluation day.
- Post-prandial sensations related to appetite in 11 time points during the evaluation day
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Other
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy male or female
- •Ages 18-30 years
- •BMI: 18-27.5 kg/m2
- •Stable weight over the last 3 months (body weight changes<35kg)
- •Participant must be capable and willing to provide consent, understand exclusion criteria, instructions and protocols.
Exclusion Criteria
- •History of cardiovascular disease
- •Diabetes or hypertension
- •Pregnant, planning to become pregnant, or breastfeeding
- •Have been treated previously or during the study period with prescription drugs: antihypertensive, lipid lowering, acid uric lowering, glucose lowering, beta blockers or any drug that under the investigator's judged could influence the results.
- •Hematological pathology
- •Have had a blood transfusion or severe blood loss within the last 3 months
- •Allergy/intolerance to milk proteins, fish, soy, and/or any ingredient of the mixed meal
- •Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
- •Claustrophobia
- •Needle phobia
- •Are deemed unsuitable by the investigator for any other reason, that prevent data collection.
Outcomes
Primary Outcomes
Post-prandial nutrient oxidation
Time Frame: 4 hours
Fat or carbohydrate oxidation measured by indrect calorimetry
Secondary Outcomes
- Post-prandial sensations related to appetite(4 hours)
- Post-prandial blood insulin concentrations(4 hours)
- Post-prandial blood cholesterol concentrations(4 hours)
- Post-prandial blood lactate concentrations(4 hours)
- Post-prandial blood non-esterified fatty acid concentrations(4 hours)
- Post-prandial blood tryglicerides concentrations(4 hours)
- Post-prandial blood glycerol concentrations(4 hours)
- Post-prandial energy expenditure(4 hours)
- Post-prandial blood glucose concentrations(4 hours)
Investigators
Jonatan Ruiz Ruiz
Associate professor
Universidad de Granada