Primary prophylaxis with ciprofloxacin improves survival and reduces bacterial infections in patients with cirrhosis and ascites

Not Applicable

Completed

• Conditions: Cirrhotic patients with ascites; Digestive System; Cirrhosis

• Registration Number: ISRCTN25761503
• Lead Sponsor: The Health Council of Investigation of the Government of Buenos Aires (Argentina)

Brief Summary

2008 results in: https://www.ncbi.nlm.nih.gov/pubmed/18316137 (added 09/05/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2005-12-01
• Study Start: 2007-02-09
• Last Update Posted: 27 May 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Diagnosis of cirrhosis was based in clinical, biochemical, ultrasonographic and histological criteria.

Inclusion criteria were:
1. Aged more than 18 and less than 80 years
2. Total protein in ascitic fluid less than 1.5 g/dl
3. Ability to give written informed consent

Exclusion Criteria

1. A previous episode of SBP
2. Antibiotics in the previous 30 days
3. Pregnancy
4. Active gastrointestinal bleeding
5. Encephalopathy more than grade two
6. Hepatocarcinoma or other malignancies
7. Allergy to quinolones
8. Serum creatinine more than 3 mg/dl
9. Bacterial infection

Study & Design

• Study Type: Interventional
• Study Design: Not specified