NCT00740168已完成不适用
Analysis of Retinal Vessel Reaction and Monitoring of Circulation Parameters During Bevacizumab Therapy
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Diameter of retinal vessels and dynamic vessel reaction
研究概览
简要总结
Bevacizumab might influence the dynamic vessel function after being administered intravenously.
详细描述
By monitoring different vessel and circulation parameters (e.g. dynamic retinal vessel analyzer) the study will clarify the potential hemodynamic effects of bevacizumab.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who wish and need bevacizumab treatment for underlying disease
排除标准
- •previous bevacizumab treatment
- •known eye disease, eye surgery or eye trauma in history
- •myopia >-2.0 dpt
- •hyperopia > +2.0 dpt.
- •relevant media opacity of the lens
- •acute heart disease, ischemic insult, proven coronary heart disease
- •cardiac arrhythmia or vessel anomalies
- •seizure disorder or episode in history
- •treatment with corticosteroids within 4 weeks before study inclusion
- •intake of vasoactive drugs like AT-1 or glitazone
- •pregnancy
研究组 & 干预措施
TG
Bevacizumab treatment group with metastasized cancer
干预措施: bevacizumab treatment (Drug)
结局指标
主要结局
Diameter of retinal vessels and dynamic vessel reaction
时间窗: Measurements before and after administration
次要结局
- Baroreflex sensitivity, heart frequence variability, reaction to handgrip test(Measurements before and after administration)
研究者
研究点 (1)
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