EEG in patients with acute stroke: detection of secondary deterioration and outcome predictio

Completed

Conditions: cerebrovascular accident
ischemic stroke
10007963

Registration Number: NL-OMON47253

Lead Sponsor: Rijnstate Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

-Age 18 years or older
-Diagnosis of acute stroke
-Possibility to start EEG monitoring within 48 hours from symptom onset
-Admission to the stroke unit
-Neurological deficit with a National Institutes of Health Stroke Scale (NIHSS) score *2
-Degree of disability before stroke on modified Rankin Scale (mRS) score <3 (no symptoms at all, no significant disability, or a slight disability)

Exclusion Criteria

- Any progressive brain illness, such as a brain tumor or neurodegenerative disease
-Expectation that the patient will die due to the stroke

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are (1) neurological deterioration during hospital<br /><br>admission (=primary outcome measure), and (2) incidence of EEG patterns that<br /><br>indicate cortical spreading depressions, epileptiform activity, infraslow<br /><br>activity, of disturbed functional connectivity in the contralesional<br /><br>hemisphere. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures will be functional outcome defined as the score on<br /><br>the mRS, the Barthel index, and major depressive disorder 6-8 weeks after<br /><br>discharge. </p><br>