Prevention of Progression Knee Osteoarthritis

Not Applicable

• Conditions: Musculoskeletal Diseases; Osteoarthritis

• Registration Number: PACTR201804003315170
• Lead Sponsor: Faculty of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-08
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

symptomatic and radiographic diagnostic criteria of early knee OA
-age 45-55 years
-Body mass index less than 30.

Exclusion Criteria

-Patients with causes of secondary KOA (e.g. rheumatoid, gouty, traumatic soft tissues and bony injuries, mechanical malalignment with varus > 10 degrees and valgus > 15 after obtaining full limb radiograghs, etc.)
-a history of knee surgery
-intra-articular injection
-use of antiresorptive drugs within the 12 months preceding enrollment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The outcome instrument for evaluation of treatment regimen efficacy on symptoms of OA was the Western Ontario and McMaster Universities (WOMAC) OA index ;The visual analog scale (VAS) ;Radiographical evaluation included 1.5 T MRI ;measurement of urinary levels of the N-terminal crosslinking telopeptide of type I collagen ;measurement of urinary levels of C-terminal crosslinking telopeptide of type II collagen

Secondary Outcome Measures

Name	Time	Method
Return to level of activity that was prior to symptoms of disease (Osteoarthritis).