Exploring the therapeutic mechanism of Batuanjin in the treatment of elderly stable angina pectoris based on gut microbiota - lipid metabolism spectrum
- Conditions
- Stable angina pectoris
- Registration Number
- ITMCTR2200006443
- Lead Sponsor
- Guang'anmen Hospital of Chinese Academy of traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) meet the diagnostic criteria of stable angina pectoris published by Chinese Medical Association in 2018 guidelines for diagnosis and treatment of chronic stable angina Pectoris.
(2) between 60 and 80 years old.
(3) patients with severe angina pectoris classified as I~III by Canadian Cardiovascular Association (CCS).
(4) those who sign the informed consent form. Those who have the above four items at the same time are included in the scope of the test.
(1) severe arrhythmia and moderate cardiac insufficiency (EF < 40%) (2) Hypertension is more than 180/100mmHg (3) patients with AMI history or percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), severe trauma and cerebrovascular accident in recent 3 months. (4) patients with severe shock and severe primary organ diseases such as liver, kidney and lung. (5) patients with obvious infection, fever and severe anemia. (6) severe joint disease, which is not suitable for those who exercise eight-paragraph jingle. (7) use antibiotics or participate in any probiotics or laxatives research in the 3 months prior to the study.(8) There were no gastrointestinal diseases such as diarrhea and ulcerative colitis in the past two months.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method total effective rate of angina pectoris symptoms;
- Secondary Outcome Measures
Name Time Method changes of trimethylamine oxide;Changes of non-targeted lipid metabolism;Serum hypersensitive C-reactive protein;Seattle angina grading;Changes in gut microbial composition;Dosage;Quality of Life Questionnaire(SF-36);The TCM syndrome scores;Duration;Electrocardiogram;blood lipid levels;Attack frequency;Stopping rate of nitroglycerin;