Temporise or Terminate pregnancy in women with severe preeclampsia at 28-34 weeks.
Completed
- Conditions
- gestational hypertensiontoxicosis10026908
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1130
Inclusion Criteria
Informed consent
Working knowledge of Dutch language
Gestational age 27.6 - 33.5 weeks at inclusion
Estimated fetal weight >= 500 gram at inclusion
No major fetal congenital anomalies
Severe preeclampsia (modified from the criteria for severe preeclampsia (ACOG practice bulletin no. 33, table 1))
Exclusion Criteria
Therapy resistant hypertension
Severe maternal complications
Fetal indication for immediate delivery
Major fetal congenital anomalies or estimated fetal weight below 500 grams
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is composite major neonatal morbidity and perinatal<br /><br>mortality. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary long-term neonatal outcome is a Bailey assessment at two years<br /><br>corrected age. The secondary short-term maternal outcome is the occurrence of<br /><br>major complications before and after delivery. The secondary long-term maternal<br /><br>outcome is persistent morbidity or death. Cost analysis calculates direct<br /><br>health care costs of mother and infant until discharge.</p><br>