The effect of whey protein on postprandial glycaemia in lean and obese males

Not Applicable

Completed

• Conditions: Central obesity and lean; Nutritional, Metabolic, Endocrine; Obesity

• Registration Number: ISRCTN95281775
• Lead Sponsor: ewcastle University

Brief Summary

2019 Other publications in https://doi.org/10.2337/db19-2276-PUB K. Smith., Taylor. G.S., Okwose, N., Allerton, D.M., Brunsgaard, L.H., Stevenson, E.J. & West, D.W. (). 2276-PUB: A Palatable, Novel Whey Protein Shot Attenuates Postprandial Glycemia in Lean and Centrally Obese Adult Males, Diabetes. 68 (supplement 1). 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34220720/ (added 06/07/2021) 2024 Other publications in https://pubmed.ncbi.nlm.nih.gov/39138690/ secondary analysis (added 15/08/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-02
• Study Completion: 2019-10-01
• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

Lean:
1. Aged between 18 – 65 years
2. BMI of 18 - 25 kg.m2
3. Weight stable for > 2 months (± 1kg) preceding the commencement of the intervention
4. Physically active as assessed by the International Physical Activity Questionnaire
5. Adhere to a normal wake/sleep cycle (i.e. non-shift workers)
6. Regularly consume breakfast

Centrally obese:
1. Aged between 18 – 65 years
2. BMI > 30 kg.m2 or waist circumference of > 102 cm
3. Weight stable for > 2 months (± 1kg) preceding the commencement of the intervention
4. Physical inactive as assessed by the International Physical Activity Questionnaire
5. Adhere to a normal wake/sleep cycle (i.e. non-shift workers)
6. Regularly consume breakfast

Exclusion Criteria

1. History of metabolic or cardiovascular diseases
2. Taking medicines that may influence gut function or satiety
3. Smokers
4. Gastrointestinal issues
5. Known food intolerance's or allergies
6. Substance abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postprandial glycaemic responses (incremental area under the curve [iAUC]) to a mixed-nutrient breakfast following prior consumption of the protein-rich supplement and control beverage (i.e. pre-load”). Glycaemic responses will be measured from venous whole blood samples over a 4-hour postprandial period. Postprandial glycaemic responses will be calculated using the trapezoidal rule and broken down into epochs depicting different stages of the postprandial period – i.e. 0-60 min (early), 120-240 min (late) and 0-240 min (total). Glucose concentrations will be determined using a commercially available assay.