Differential Sensitivity Markers in Youth Drug Abuse Prevention

Not Applicable

Completed

• Conditions: Adolescent Substance Use
• Interventions: Behavioral: Teen Intervene; Behavioral: Everyday Parenting

• Registration Number: NCT02622451
• Lead Sponsor: University of Minnesota

Brief Summary

This pilot study conducts feasibility and exploratory intervention outcome research that will lead to the development of a personalized intervention framework that seeks to preempt the progression from early drug use to more chronic abuse and dependency. The study will explore moderators representing two frameworks, risk severity and differential sensitivity. Moderators will be explored in their ability to influence the differential efficacy of two adolescent drug abuse interventions.

Detailed Description

This R34 pilot study proposes to conduct feasibility and exploratory intervention outcome research that will lead to the development of a personalized intervention framework for early stage adolescent drug users. The study will explore putative moderators representing two theoretically distinct frameworks and determine whether they are suitable candidates for a subsequent R01 study. One moderation framework is based on risk severity (RS) as reflected by individual differences in delay discounting (DD), a form of impulsive decision making that is positively associated with escalation to more serious levels of abuse and addiction. A second more exploratory framework is based on differential sensitivity (DS) theory. The DS framework stipulates that individuals, due to specific sensitivity factors, vary in their responsiveness to environmental influence such as the influence provided by an intervention. The study will explore DS markers associated with the reward motivational system, including dopaminergic genes, the post-auricular physiological reflex and a high sensory-processing sensitivity trait. An agency-university partnership will collaborate in providing services to 120 adolescents (ages 12-17) who were referred to a community counseling center because of a recent alcohol and/or marijuana incident. Recruitment will select mild/moderate drug users. Participants will be randomized to one of two evidence-based drug abuse interventions. The two interventions offer the same delivery dosage but differ in terms of their mechanism of therapeutic change (i.e., degree of environmental influence). The Teen Intervene program (TI; Winters \& Leitten, 2007) is a youth-focused intervention that uses motivational interviewing, goal setting, and skills training to foster the internal development of responsible decision-making with the goal of choosing attitudes and behaviors that are healthier alternatives to drug use behaviors. The Everyday Parenting program (EP; Dishion et al., 2003; 2010) is a family focused-intervention that works with parents to provide environmental scaffolding necessary to help teens gradually internalize decision-making skills that reinforce and promote healthy lifestyle alternatives to drug use. The aims of this R34 are to (1) assess feasibility of recruiting, assessing, and following-up enrolled youth in an intervention trial, (2) assess the ability of staff to implement TI and EP with fidelity, and (3) obtain promising data on moderator and outcome variables that will help answer the question of "what intervention works best for which youth" in a subsequent R01 study.

Study Timeline

• Study Start: 2015-12-01
• Study First Submitted: 2015-12-02
• Study First Submitted QC: 2015-12-02
• Study First Posted: 2015-12-04
• Primary Completion: 2020-03-08
• Study Completion: 2020-03-08
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-18
• Last Update Posted: 2020-09-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Youth ages 12-17
• Substance Use referral to community partner agency
• Adolescent report of weekly-monthly use of one or more substances within the prior 6 months

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Exclusion Criteria

• Current DSM-5 diagnosis of a severe substance use disorder (i.e. substance dependence)
• Adolescent report of daily use of substance within prior 6 months
• Current or past history of psychosis (including suicidal ideation)
• Pervasive developmental disabilities

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Youth Behavioral Intervention	Teen Intervene	Teen Intervene
Parent Education	Everyday Parenting	Everyday Parenting

Primary Outcome Measures

Name	Time	Method
Peer Delinquency Scale	4 months post-intervention	Youth Report
Delayed Discounting Task	4 months post-intervention	Youth Computer Task
Iowa Gambling Task	4 months post-intervention	Youth Computer Task
Urinalysis	4 months post-intervention	Adolescents will provide urine samples for urinalysis to test for recent drug usage.
Project Towards No Drug Abuse Survey	4 months post-intervention	Youth Report
Single-item self-efficacy Scale	4 months post-intervention	Youth Report
Parental Monitoring Instrument	4 months post-intervention	Parent \& Youth Report
Alcohol Expectancy Questionnaire	4 months post-intervention	Youth Report
Parenting Relationship Questionnaire (PRQ)	4 months post-intervention	Parent Report
Family Problem Solving Communication Index	4 months post-intervention	Parent Report
Conflict Behavior Questionnaire	4 months post-intervention	Parent Report
Peer Substance Use Test	4 months post-intervention	Youth Report
Client Satisfaction Questionnaire	4 months post-intervention	Parent \& Youth Report
Highly Sensitive Person Scale	4 months post-intervention	Parent \& Youth Report
Family Assessment Measure - III	4 months post-intervention	Parent Report on family functioning .
Parental Locus of Control Questionnaire	4 months post-intervention	Parent Report

Trial Locations

Locations (1)

Center for Personalized Prevention Research in Children's Mental Health; 🇺🇸 Minneapolis, Minnesota, United States