Fraction of Exhaled Nitric Oxide (FeNO) in an Occupational Cohort of Hairdressers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Daily FeNO (ppb measured by Niox Vero) increase after occupational exposure.
研究概览
简要总结
A 5-day cohort diurnal FeNO study of exposed and unexposed to airway irritants during hair treatments and commuting.
详细描述
The project aims to increase the knowledge of daily variations in FeNO with emphasis on exposure of airway irritants during hairdressing treatments in an occupational setting and commuting. Daily measurements of FeNO before and after workplace exposure in an exposed and an unexposed cohort during a workweek (Monday to Saturday) will indicate patterns of proinflammatory responses in a dose-dependent manner. These may or may not be indicative of an increased risk for airway related disease. Results may be used for further studies of occupational hygiene, airway related disease and identification of endogenous volatile organic compounds during proinflammatory responses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •have given informed consent.
- •employed as hairdressers or at Oslo University Hospital as healthcare workers.
- •scheduled work for at least 3 hours daily for 5 days in the study week.
排除标准
- •lung disease.
- •active smoker.
结局指标
主要结局
Daily FeNO (ppb measured by Niox Vero) increase after occupational exposure.
时间窗: 1 day.
At start of work and after 3 hours. Hardressers vs. Health care workers.
Daily FeNO (ppb measured by Niox Vero) increase after enviromental exposure during commuting.
时间窗: 1 day.
At start of work and after 3 hours. Subgrouped after way of commuting.
Diurnal FeNO (ppb measured by Niox Vero) variations during a work week after occupational exposure.
时间窗: 6 days
At start of work and after 3 hours. Hardressers vs. Health care workers.
Diurnal FeNO (ppb measured by Niox Vero) variations during a work week after environmental exposure during commuting.
时间窗: 6 days
At start of work and after 3 hours. Subgrouped after way of commuting.
次要结局
未报告次要终点
研究者
Bato Hammarstrøm
Senior consultant
Oslo University Hospital