Micronutrient Status Involved in Immunity in Elderly Patients With COVID-19

Completed

• Conditions: Covid19
• Interventions: Biological: Selenium, Zinc and Copper, Vitamin A, D, E plasma concentrations during patient hospitalization

• Registration Number: NCT04877509
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

During the ongoing COVID-19 pandemic, age was clearly the major factor of mortality. Increasing age was strongly associated with this risk, with the upper 80 years age group having more than 12-fold increased risk compared with those aged 50-59 years. Male gender was also associated with a doubling of risk.

The elderly subject is particularly exposed to global denutrition with risk of micronutrients deficiencies such as vitamins and trace elements. Those deficits expose to lower immunity. In addition, viral infection as COVID-19 can also worsen these deficits.

In general, low levels or intakes of micronutrients such as Zn, Se and vitamin A have been associated with adverse clinical outcomes during viral infections. This notion has been confirmed in a recent review proposing that besides vitamins A and D also B vitamins, vitamin C, omega-3 polyunsaturated fatty acids, as well as selenium, zinc and iron should be considered in the assessment of micronutrients in COVID-19 patients.

In this context, the MicroCovAging study will evaluate copper, zinc and selenium, vitamin A, D and E status in elderly subjects affected by COVID- 19 and to correlate this status with prognosis of this disease.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2020-03-01
• Primary Completion: 2020-12-01
• Status Verified: 2021-03
• Study First Submitted: 2021-03-04
• Study Completion: 2021-05-01
• Study First Submitted QC: 2021-05-05
• Last Update Submitted: 2021-05-05
• Study First Posted: 2021-05-07
• Last Update Posted: 2021-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 229

Inclusion Criteria

• Hospitalized adult patient ≥ 50 years at the time of admission,
• Suffering from confirmed COVID-19 (positive quantitative PCR for SARS-CoV-2 and/or chest scanner suggestive of COVID-19),
• Informed and non-opposed to the research. Patient will be informed of the study by his medical doctor during hospitalization or by post thanks to a generic information sheet dedicated to COVID-19 researches.

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Exclusion Criteria

• Adult patient < 50 years at the time of admission
• Negative quantitative PCR for SARS-Cov-2

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Over 50 year's COVID-19 patients hospitalized at HCL from 1st March to 29th May 2020.	Selenium, Zinc and Copper, Vitamin A, D, E plasma concentrations during patient hospitalization	-

Primary Outcome Measures

Name	Time	Method
Selenium, Zinc and Copper, Vitamin A, D and E plasma concentrations of 229 over 50 year's patients hospitalized suffering from COVID-19.	Up to 3 months

Trial Locations

Locations (1)

Chls Cbap; 🇫🇷 Pierre-Bénite, France