The influence of differing inspired oxygen concentrations on platelet function in a model of ischaemic reperfusion injury
Not Applicable
- Conditions
- Ischaemic reperfusion injuriesBlood - Clotting disordersAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12609000183280
- Lead Sponsor
- Royal Perth Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
1. Adult patients undergoing upper limb surgery that requires the use of a tourniquet for more than 45 minutes
2. American Society of Anaesthesiology (ASA) grade 1 or 2
Exclusion Criteria
1. Patients taking any antiplatelet medication
2. Confirmed coagulation disorder (pathological or drug induced)
3. Platelet count less then 80 x 109/l
4. Blood urea greater than 8.0 mmol/L
5. Systemic infection
6. Confirmed systemic Inflammatory diseases
7. Documented pregnancy
8. Documented malignancy
9. Trauma other than the ipsilateral upper limb
10. Multiple tourniquet episodes
11. Likely intraoperative O2 requirement > 30%
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method