Effects of Dietary Inorganic Nitrate Supplementation on Exercise Performance in Heart Failure

Not Applicable

Completed

• Conditions: Heart Failure Preserved Ejection Fraction (HFpEF); Heart Failure Reduced Ejection Fraction (HFrEF); Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12615000906550
• Lead Sponsor: Jason Allen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Recruitment will be for individuals between the ages of 18 and 85 who have diagnosed stable Heart Failure ((HF) with either reduced ejection fraction of less than or equal to 40 percent (HFrEF) or preserved ejection fraction of greater than or equal to 50 percent (HFpEF) andno major changes in medications for at least 3 months.

Additional inclusion criteria include: NYHA class II-III HF; receiving optimal medical therapy and a peakVO2 between 10 and 30 ml/kg/min. Furthermore HFpEF inclusion criteria includes: evidence of diastolic dysfunction via an echocardiography (ECHO) or brain natriuretic peptide (BNP).

Exclusion Criteria

A major cardiovascular event or procedure within the previous 6 weeks or plans for hospitalisation or cardiac transplantation within the next 2 months; foot ulcers/Advanced neuropathy; abnormal responses to cardiopulmonary exercise testing (CPX) as defined by AACVPR or other co-morbidities or limitations that preclude safe participation in the exercise testing; inability to walk on treadmill; Allergy to beets, beet juice, milk or soy; Refusal or inability to abstain from the use of proton pump inhibitors for 24 hours prior to testing visits.

Study & Design

• Study Type: Interventional
• Study Design: Not specified