To evaluate the effect of virechana (purgation) and varunadi ghan vati on Poly cystic ovarian syndrome.

Phase 2/3

Not yet recruiting

Conditions: Polycystic ovarian syndrome. Ayurveda Condition: GRANTHIBUTA-ARTAVADUSHTIH,

Registration Number: CTRI/2022/08/044876

Lead Sponsor: University Post Graduate Institute of Ayurved Studies and Research Jodhpur Rajasthan

Brief Summary: Polycystic Ovarian Syndrome is the most common disease in the female population among adolescence and reproductive age group mainly due to the adoption of westernized culture.and due to change in the lifestyle and increasing Stress. Prevalence of PCOS has reported incidence rate of 2.2% to 26% worldwide & in india ranges from 3.7-22.5% depending on the criteria used for diagnosis. PCOS is a heterogeneous Disorder presenting with irregular menstruation, infertility due to anovulation, polycystic Ovaries, hyperandrogenism (hirsutism,acne), insulin resistance, obesity, type 2 diabetes and raised cholesterol levels Besides Infertility, other symptoms associated with PCOS (like hirsutism, obesity, acne and weight Gain) can affect self-esteem of the women. It thus affects the women on all levels- physical,Mental and psychological levels.

To assess the efficacy of *â€œVIRECHANAâ€* with *â€œTRIVRIT MODAKâ€* &*â€œVARUNADI GHAN VATIâ€*in the management of PCOS.

Virechana does *shodhana* by removal of *aavarana , vata anulomana* and catering the normal functioning of *dosha. & virechana* also increases the bio availability of drugs by opening channels & improve the assimilation of trial drug.*Varunadi ghan vati* is adopted as *shaman chikitsa* on the basis of its actions opposite to this disease. content of *varunadi ghan vati* is *varuna , shigru, .* These drug having properties like *pittavardhaka, vatakaphahara ,Bhedana,granthiharaguna* which are also present in drugs used in previous researches which are useful in decreasing the size of cyst & formation of *artava* and helpful for correcting the menstrual irregularties & pcos ovary.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 30

Inclusion Criteria

1.Patients diagnosed cases of PCOS by the Rotterdam criteria 2.Age: Patients aged between 16-40 years.
3.The patients who are fit for the virechana procedure were only considered for The study.
4.Patients willing for Informed consent.

Exclusion Criteria

1.Known congenital adrenal hyperplasia, androgen secreting tumors were excluded which also present the complaints of oligomenorrhea or irregular cycles and anovulation.
2.Other endocrinal disorders like Cushingâ€™s syndrome were excluded as they also precipitate the pathology of PCOS.
3.The patients with BMI > 30 are considered to be morbidly obese and are not fit for the panchakarma procedures.
Hence they were not considered for the study.
4.The patients suffering with rectal pathologies like fissure, fistulas were excluded.
5.The patients who were unfit for virechana procedure were excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in ovarian size ,volume ,stromal pattern , and in menstrual irregularities.	60 days

Secondary Outcome Measures

Name	Time	Method
Improvement in FBS , lipid profile , BMI ,WHR Ratio ,and on acne , Hirsutism.	60 days

Trial Locations

Locations (1): University Post Graduate Institute of Ayurved Studies and Research Jodhpur Rajasthan
🇮🇳
Jodhpur, RAJASTHAN, India
University Post Graduate Institute of Ayurved Studies and Research Jodhpur Rajasthan
🇮🇳Jodhpur, RAJASTHAN, India
Dr Divya rajpurohit
Principal investigator
6376539436
divyabarwa1997@gmail.com