Observation of Microvessels and Invasion in Early Colorectal Lesions by Narrow Band Imaging:Combination With Microvessel Count and MMP-7 Expression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 418
- 主要终点
- NBI prediction for lesion histology and invasion
研究概览
简要总结
Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating invasion depth remains to be verified.The study is based on the hypothesis:NBI can predict histology and invasion depth,combined with the verification of microvessel count and MMP-7 expression.
详细描述
The microvessel count (MVC) is a classical method of assessing histologic grade.To verify whether NBI could predict histology through microvascular architecture,we measured lesion microvessels by immunohistochemistry.On the other hand,we applied immunohistochemistry of matrix metalloproteinase-7 (MMP-7) to validate the capability of NBI for estimating invasion depth.MMP-7 is directly involved in the processes of growth, invasion, and metastasis of colorectal cancer.Our target was to clarify the diagnostic accuracy of magnifying NBI in early colorectal lesions,combined with the verification of microvessel count and MMP-7 expression.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients of early colorectal lesions with capillary pattern(CP) type II&III,initially detected by white-light view and then examined by NBI with magnifying endoscopy.
排除标准
- •lesions with CP type I;
- •CP type III lesions with an obvious appearance of advanced cancer;
- •lesions that had underwent biopsy;
- •patients with inflammatory bowel disease(IBD) or familial adenomatous polyposis(FAP)
- •patients with previous colorectal surgery;
- •having conditions associated with cardiac,hepatic,renal,and coagulopathy diseases.
结局指标
主要结局
NBI prediction for lesion histology and invasion
时间窗: in two weeks after lesion treatment
We will receive the histologic findings in two weeks after lesion treatment.Then we can compare NBI prediction with the final histologic type.
次要结局
- immunohistochemical outcome of microvessel count and MMP-7(in three days after immunohistochemistry)
研究者
Xiaobo Li
Shanghai Institute of Digestive Disease，Renji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai Jiao Tong University School of Medicine