To compare the effects of two modes of ventilation (airway pressure release ventilation and pressure regulated volume control) in surgical patients admitted in icu requiring ventilator support

Phase 4

• Conditions: Health Condition 1: O- Medical and SurgicalHealth Condition 2: K631- Perforation of intestine (nontraumatic)

• Registration Number: CTRI/2023/01/049278
• Lead Sponsor: Director Principal

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Patients on invasive mechanical ventilation and admitted in ICU following exploratory Laparotomy due to acute respiratory failure (ARF) for less than 24 hours

2. Age group 18-60 years

3. Stable hemodynamic parameters (Mean Arterial Pressure between 70 mm Hg and 100 mm Hg, heart rate between 60 and 100/minute, SPO2 >= 90%)

4. Richmond Agitationâ??Sedation Scale (RASS) between 0 and -2

Exclusion Criteria

1. Pregnant and morbidly obese patients (BMI >35)

2. Patient diagnosed with acute respiratory distress syndrome (ARDS) (Mild, Moderate, or Severe) according to Berlinâ??s definition.

3. Patients with severe or chronic heart, lung, hepatic or renal disease

4. Patients with severe neuromuscular disorders

5. Patient on vasopressors, cardiac depressants or neuromuscular blockers

6. Patient with traumatic brain injury

7. Patient with blunt or traumatic chest injury

8. Patients with severe multiple organ dysfunction.

Study & Design

• Study Type: Interventional
• Study Design: Not specified