Effect of mechanical ventilation on intracranial pressure
Not Applicable
- Conditions
- traumatic brain injuries.Other intracranial injuries, Intracranial injury with prolonged coma,Traumatic subarachnoid haemorrhage,Traumatic subdural haemorrhage,Diffuse brain injury,Focal brain injury,Epidural haemorrhage,s06.2, s06
- Registration Number
- IRCT2015070623104N1
- Lead Sponsor
- Mashhad University of Medical Sciences, research assisstance
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
age between 18 and 70 years; traumatic brain injuries who are intubated and under mechanical ventilation with SIMV mode; stable hemodynamic (MAP more than 70 mm Hg for at least 30 minutes before the start of the study); Glasgow Coma Scale <9 ; no history of chronic obstructive pulmonary disease (COPD); ratio of arterial oxygen to inspired oxygen fraction <400; having intraventricular catheter for ICP monitoring; ICP > 10 mm Hg. Exclusion criteria: unstable hemodynamic (MAP <70); CPP <60 mmHg; ICP > 25 mmHg; pneumothorax
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intracranial pressure. Timepoint: Before and half an hour after the intervention. Method of measurement: Intraventricular catheter -mmHg.;Pressure of arterial oxygen. Timepoint: Before and half an hour after the intervention. Method of measurement: mmHg.;Arterial oxygen saturation. Timepoint: Before and half an hour after the intervention. Method of measurement: Pulseoxymetry- percent.;Ratio of arterial oxygen to inspired oxygen fraction. Timepoint: Before and half an hour after the intervention. Method of measurement: number.
- Secondary Outcome Measures
Name Time Method Mean arterial pressure. Timepoint: Before and after half an hour the intervention. Method of measurement: Barometer- mmHg.;Cerebral perfusion pressure. Timepoint: Before and after half an hour the intervention. Method of measurement: Calculation formula- mmHg.