COVID-19 in Hospitalised Norwegian Children - Risk Factors, Outcomes and Immunology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Risk Factors for severe infection
研究概览
简要总结
Prospective cohort study of COVID-19 infection among children in Norway.
详细描述
This nation-wide, prospective cohort study of COVID-19 infection addresses three main issues: 1) Epidemiological risk factors; 2) Natural history (including immunological mechanisms and long term effects) and 3) Support of infection prevention. Also, the study focuses solely on children.
Children (0-18 years of age) admitted to hospital with suspected COVID-19 are eligible (Fig. 1). Those with confirmed COVID-19 serve as cases, whereas those with non-COVID-19 serve as controls; both groups will be followed prospectively for 6 months. Three objectives/Work Packages (WPs) are defined:
- In WP1, the investigators will investigate risk factors for severe outcome of the acute infection; potential risk factors include sex, age, comorbidities, initial clinical findings, infectious load, and genetic markers.
- In WP2, the investigators will investigate the immunological response to acute infection, focusing on initial innate host response and its associations to inflammatory enhancement, genetic factors and clinical course.
- In WP3, the investigators will investigate the prevalence and risk factors of long-lasting complication, in particular the development of post-infectious chronic fatigue
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected covid-19 infection and age 0-18 years
排除标准
- •Age >18 years
结局指标
主要结局
Risk Factors for severe infection
时间窗: 2030
Identify comorbidities predisposing for severe infection
Immunulogical mechanisms
时间窗: 2030
Immunological response to acute infection, focusing on initial innate host response and its associations to inflammatory enhancement, genetic factors and clinical course.
Long term outcome
时间窗: 2030
prevalence and risk factors of long-lasting complication, in particular the development of post-infectious chronic fatigue
次要结局
未报告次要终点
研究者
Christopher Inchley
Principal investigator
University Hospital, Akershus