A Nutritional Approach to Minimal Hepatic Encephalopathy
Not Applicable
- Conditions
- Minimal Hepatic Encephalopathy
- Interventions
- Other: Nutritional Intervention
- Registration Number
- NCT01083446
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Brief Summary
This trial will study a possible effect of standard Israeli breakfast (30% of caloric value and 21 gram protein) on cognitive and executive functions (working memory, visual memory, concentration and coordination), on patients with mild-moderate liver cirrhosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- All consented adults (age > 18), with the diagnosis of CHILD A cirrhosis with MELD score of < 10.
- Diagnosis of liver cirrhosis as documented by liver biopsy (stage IV) and / or fibroscan (score > 12 kpa) and / or fibrotest (score > 0.74) and /or imaging.
Exclusion Criteria
- History of > grade II hepatic encephalopathy (HE).
- Diagnosis of dementia, Parkinson disease, Schizophrenia (Patients with major depression will be noted but not excluded).
- Use of sedatives, tranquilizers or anti- psychotic medication during and/or 2 weeks prior to enrolling Use of antibiotics for any length of period during and/or 2 weeks prior to enrolling.
- Current use of lactulose or neomycin.
- Use of alcohol or elicit drugs during and/ or 6 months prior to enrolling.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description B Nutritional Intervention Nutritional Intervention, fast A Nutritional Intervention Nutritional intervention, standard Israeli breakfast
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel