The Ventilation During In-hospital Cardiac Arrest Study

Recruiting

• Conditions: Cardiac Arrest (CA); In-Hospital Cardiac Arrest; Heart Arrest

• Registration Number: NCT06809309
• Lead Sponsor: University of Aarhus

Brief Summary

The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.

The main questions it aims to answer are:

What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?

Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-20
• Study First Submitted QC: 2025-01-29
• Study Start: 2025-02-01
• Study First Posted: 2025-02-05
• Last Update Submitted: 2025-04-03
• Last Update Posted: 2025-04-06
• Primary Completion: 2026-12
• Study Completion: 2027-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 900

Inclusion Criteria

1. In-hospital cardiac arrest
2. Age ≥ 18 years
3. >1minute of recorded ventilation data

Exclusion Criteria

1. Documented do-not-attempt cardiopulmonary resuscitation order
2. Invasive mechanical circulatory support at the time of the cardiac arrest

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fraction of patients with return of spontaneous circulation (ROSC)	ROSC is assessed immediately following cardiopulmonary resuscitation.	ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.

Secondary Outcome Measures

Name	Time	Method
Fraction of patients surviving until day 30	Assessed at day 30 after cardiac arrest.	Patient survival for at least 30 days following cardiac arrest.

Trial Locations

Locations (5)

Aalborg University Hospital; 🇩🇰 Aalborg, Denmark

Gødstrup Regional Hospital; 🇩🇰 Gødstrup, Denmark

Horsens Regional Hospital; 🇩🇰 Horsens, Denmark

Randers Regional Hospital; 🇩🇰 Randers, Denmark

Viborg Regional Hospital; 🇩🇰 Viborg, Denmark