A randomised controlled trial of the benefits of exercise early in the management of Type 2 diabetes

niversity of Bristol (UK)0 sites593 target enrollmentJuly 25, 2005

Overview

2011 Results article in http://www.ncbi.nlm.nih.gov/pubmed/21705068 2014 Other publications in http://www.ncbi.nlm.nih.gov/pubmed/24811615 Effect on inflammatory markers 2018 Other publications in https://www.ncbi.nlm.nih.gov/pubmed/29386030 Qualitative analysis of motivation 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35430794/ Analysis of association of glycaemic control with diet independent of weight change (added 19/04/2022)

Registry

who.int

Start Date

July 25, 2005

End Date

July 31, 2008

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity of Bristol (UK)

•This a multicentre trial recruiting 750 participants from across the South West of England. Individuals must satisfy the following criteria before they can be considered eligible:
•1\. Type 2 diabetes mellitus (T2DM) as defined by: body mass index (BMI) \>25, no ketosis, no significant weight loss prior to diagnosis, aged above 30 at diagnosis
•2\. Between 5 and 8 months from clinical diagnosis of T2DM

•1\. Age over 80 at diagnosis
•2\. HbA1c of greater than 10%
•3\. Blood pressure greater than 180/100
•4\. Low\-density lipoprotein (LDL) greater than 4
•5\. Patients already receiving a maximum dose of a sulphonylurea
•6\. Have a current diagnosis of unstable angina
•7\. Have had a myocardial infarction within the previous three months
•8\. Unable to increase their physical activity
•9\. Subject is pregnant or is of childbearing age and not surgically sterile, 2 years postmenopausal or does not practice one method of contraception