Detection and Treatment of Depression in Patients Admitted to the General Hospital

Phase 2

• Conditions: Depressive Disorder; Depression
• Interventions: Behavioral: Cognitive Behavioural Therapy

• Registration Number: NCT00521911
• Lead Sponsor: Radboud University Medical Center

Brief Summary

Depression is a common disorder among patients with a somatic illness admitted to the general hospital. Patients with depression do worse in terms of their somatic symptoms or functioning that those without depression. They also stay in the hospital for longer.

That is the reason that we are interested to know whether patients with depression do better if their depression is recognised earlier and treated appropriately. We would like to find out which questionnaires are most suitable in clinical practice to help pick up patients with a depression. In addition, we would like to know whether a short-term psychological treatment of depression would be of any help. We hope to be able to show that this treatment would not only result in a reduction of depressive symptoms, but also in a better and quicker recovery of the somatic illness.

The treatment will consist of 6 to 9 weekly sessions of one hour, conducted by a cognitive behavioural assistant. Initially, the treatment will take place in the hospital. When patients are discharged, treatment sessions will continue at home. The treatment will focus on things like recognising and challenging unhelpful thoughts, planning of activities, and testing out of predictions by setting up behavioural experiments. Three monthly booster sessions will be offered to help patients to maintain their gains and prevent relapse. We will reassess the symptoms of the patients at three and six months after the end of treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-08
• Study First Submitted: 2007-08-27
• Study First Submitted QC: 2007-08-27
• Study First Posted: 2007-08-28
• Status Verified: 2008-12
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Last Update Submitted: 2008-12-24
• Last Update Posted: 2008-12-25

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Depressive Disorder

Exclusion Criteria

• Severe Physical Disfunction
• Severe Cognitive Disfunction
• Speech and/or Hearing Disorder
• Limited knowledge of the Dutch language

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Cognitive Behavioural Therapy	Cognitive Behavioural Therapy

Primary Outcome Measures

Name	Time	Method
Depressive Disorder Physical symptoms	9 months

Secondary Outcome Measures

Name	Time	Method
- Functional impairment (RAND 36) - Cost-effectiveness (TiC-P) - Quality of Life (EQ5D)	9 months

Trial Locations

Locations (1)

Radboud University Nijmegen Medical Centre; 🇳🇱 Nijmegen, Gelderland, Netherlands