The effect of alternating energy intake compared to regular energy intake on the fat content in the blood after a meal in abdominally obese adults
- Conditions
- 'Lipid metabolism' and 'postprandial lipemia'10013317
- Registration Number
- NL-OMON52304
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 23
* Apparently healthy men and women as judged by study physician
* Abdominally obese males (waist circumference * 102 cm) and females (waist
circumference * 88 cm)
* Aged between 18 * 75 years
* Stable bodyweight (weight gain or loss * 3 kg in the past three months)
* Willingness to give up being a blood donor (or having donated blood) from 8
weeks before the start of the study, during the study and for 4 weeks after
completion of the study
* Women should be pre- or postmenopausal
* No difficult venipuncture as evidenced during the screening visit
* Sedentary (light exercise < 1 h per week) or moderately active (moderate
exercise 1-2 h per week)
* Having a general practitioner
* Agreeing that the participant and general practitioner will be informed about
medically relevant personal test results by a physician
* Willing to comply to study protocol during study
* Informed consent signed
* Fasting plasma glucose * 7 mmol/l
* Fasting serum triacylglycerol * 4.5 mmol/l
* Fasting serum total cholesterol * 8 mmol/l
* Blood pressure * 160/100 mm Hg
* Current smoker, or smoking cessation < 12 months
* Drug abuse
* Alcohol abuse (* 21 alcohol consumptions per week)
* Use of medication known to affect blood pressure, serum lipid metabolism, or
glucose metabolism
* Having a medical condition or history which might impact study measurements,
to be judged by the study physician (e.g. myocardial infarction, angina,
thrombosis, stroke, cancer, familiar hypercholesterolemia, liver or bowel
disease or diabetes)
* Active cardiovascular disease like congestive heart failure or cardiovascular
event, such as an acute myocardial infarction or cerebrovascular accident
* Use of an investigational product within another biomedical intervention
trial within the previous 1-month
* Women who are perimenopausal, have an irregular menstrual cycle, or are
pregnant
* Use of over-the-counter and prescribed medication, which may interfere with
study measurements (to be judged by the principal investigator), e.g. weight
loss medication
* Reported dietary habits: medically prescribed diets or slimming diets
* Reported participation in night shift work 2 weeks prior to screening and/or
during the study. Night work is defined as working between midnight and 6.00 AM
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint of the study is the difference in the area under the curve<br /><br>(AUC) for TAG after a mixed meal challenge between the end of the 4-<br /><br>week alternating and regular eating schedules. Secondary endpoints include<br /><br>fasting lipid metabolism, fasting glucose metabolism, and postprandial<br /><br>glycaemic responses.</p><br>
- Secondary Outcome Measures
Name Time Method