Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 主要终点
- Incidence of Acute respiratory distress syndrome (ARDS)
研究概览
简要总结
The purpose of this piece of research is to assess the effect of altitude on the clinical evolution of ARDS. For this purpose, patients who live and receive care at sea level are compared with those who live and receive care at high altitudes. For reasons of convenience, a cut-point of 1500 meters above sea level was chosen. In addition to this, it will be sought to assess whether adjusting the cut-points for the severity categories of ARDS improves the ability to predict some adverse events, by comparison with unadjusted cut-points. The results of this research will probably be disruptive, and will provide the first information yet about the effect of altitude on ARDS; they will therefore be of great interest for the international scientific community and for the direct care of patients. A high bibliometric impact is to be expected.
详细描述
HYPOTHESIS
Physiological adaptations generated by living at high altitude modify the clinical evolution of ARDS.
OBJECTIVE
To describe the main clinical and developmental characteristics of ARDS diagnosed at altitudes greater than 1500 meters above sea level.
To compare the main clinical and developmental characteristics of ARDS diagnosed at altitudes greater than 1500 meters above sea level with those of cases diagnosed at altitudes below 1500 meters above sea level.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Berlin definition of ARDS
- •Pa02/FiO2 ≤ 300 (not corrected for altitude)
- •Invasive mechanical ventilation
- •Age >16 years
- •Informed consent
- •The patient stayed at the same altitude for at least 40 days prior to ICUadmission
- •Exclusion criteria:
- •Pregnancy
- •Under 16 years
- •Not accept informed consent
排除标准
- 未提供
结局指标
主要结局
Incidence of Acute respiratory distress syndrome (ARDS)
时间窗: 1 month
次要结局
- Duration of mechanical ventilation of patients with Acute respiratory distress syndrome (ARDS)(1 month)
- Length of ICU stay of patients with Acute respiratory distress syndrome (ARDS)(1 month)
- Mortality of Acute respiratory distress syndrome (ARDS)(1 month)
研究者
Guillermo Ortiz Ruiz
MD PhD(c)
Red Latinoamericana de Medicina Intensiva de Altura