Effect of High Altitude Exposure, Acclimatization and Re-exposure on Cerebral Autoregulation in Lowlanders
- Conditions
- Effect of High Altitude
- Registration Number
- NCT02829255
- Lead Sponsor
- University of Zurich
- Brief Summary
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on cerebral autoregulation
- Detailed Description
Baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the ALMA base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 8 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing testing as described above at the first and the last day at 5050m. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.
A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
- Born, raised and currently living <800m
- No overnight stay at altitudes >1500 m 4 weeks before the study
- Previous altitude intolerance to altitude <3000 m
- Pregnancy
- Health impairment, which requires regular treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Coherence between middle cerebral artery blood flow velocity and systemic blood pressure as measure of cerebral autoregulation. day 1; day 2 first cycle Change in magnitude of the coefficient of coherence between blood flow velocity in the middle cerebral artery measured by transcranial ultrasound Doppler and systemic blood pressure at day 2 (5050 m) vs. day 1 (520 m) of the first cycle
- Secondary Outcome Measures
Name Time Method Coherence between middle cerebral artery blood flow velocity and systemic blood pressure as measure of cerebral autoregulation. day 7 first cycle; day 7 second cycle Change in magnitude of the coefficient of coherence between blood flow velocity in the middle cerebral artery measured by transcranial ultrasound Doppler and systemic blood pressure at day 7 (5050 m) second cycle vs. day 7 (5050 m) of the first cycle.
Trial Locations
- Locations (1)
University of Zurich
🇨🇭Zurich, Switzerland
University of Zurich🇨🇭Zurich, Switzerland