Effect of High Altitude Exposure, Acclimatization and Re-exposure on Cerebral Autoregulation in Lowlanders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Coherence between middle cerebral artery blood flow velocity and systemic blood pressure as measure of cerebral autoregulation.
研究概览
简要总结
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on cerebral autoregulation
详细描述
Baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the ALMA base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 8 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing testing as described above at the first and the last day at 5050m. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.
A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Born, raised and currently living <800m
- •No overnight stay at altitudes >1500 m 4 weeks before the study
排除标准
- •Previous altitude intolerance to altitude <3000 m
- •Pregnancy
- •Health impairment, which requires regular treatment
研究组 & 干预措施
Altitude exposure
Acute high altitude exposure followed by 8 day acclimatization and reexposure for 8 days after 6 days at low altitude
干预措施: altitude exposure (Other)
结局指标
主要结局
Coherence between middle cerebral artery blood flow velocity and systemic blood pressure as measure of cerebral autoregulation.
时间窗: day 1; day 2 first cycle
Change in magnitude of the coefficient of coherence between blood flow velocity in the middle cerebral artery measured by transcranial ultrasound Doppler and systemic blood pressure at day 2 (5050 m) vs. day 1 (520 m) of the first cycle
次要结局
- Coherence between middle cerebral artery blood flow velocity and systemic blood pressure as measure of cerebral autoregulation.(day 7 first cycle; day 7 second cycle)