Effect of High Altitude Exposure, Acclimatization and Re-exposure on Nocturnal Breathing Pattern in Lowlanders
- Conditions
- Effect of High Altitude
- Registration Number
- NCT02730143
- Lead Sponsor
- University of Zurich
- Brief Summary
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure of high altitude on nocturnal breathing pattern.
- Detailed Description
Respiratory polygraphies will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the ALMA base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 7 nights and respiratory polygraphies will be performed on night 1 and 6. They will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing physiological testing. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.
A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
- born, raised and currently living <800m
- No overnight stay at altitudes >1500 m 4 weeks before the study
- Previous altitude intolerance to altitude <3000 m
- Pregnancy
- Health impairment, which requires regular treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Mean nocturnal oxygen saturation measured by pulse oximetry first sojourn at 5050 m, night 1, 6; second sojourn at 5050 m, night 1, 6; low altitude sojourn at 520 m, night 1 Change in mean nocturnal oxygen saturation over the course of high altitude exposure during 2 sojourns at 5050 m compared to low altitude
- Secondary Outcome Measures
Name Time Method Acute mountain sickness measured by the Environmental Symptom questionnaire cerebral score (AMSc) first sojourn at 5050 m, day 2, 7; second sojourn at 5050 m, day 2,7; low altitude sojourn at 520 m, day 2 Incidence of acute mountain sickness (AMSc score \>= 0.7) over the course of high altitude exposure during 2 sojourns at 5050 m compared to low altitude
Oxygen desaturation index measured by respiratory polygraphy first sojourn at 5050 m, night 1, 6; second sojourn at 5050 m, night 1, 6; low altitude sojourn at 520 m, night 1 Change in oxygen desaturation index over the course of high altitude exposure during 2 sojourns at 5050 m compared to low altitude
Apnea-/hypopnea index measured by respiratory polygraphy first sojourn at 5050 m, night 1, 6; second sojourn at 5050 m, night 1, 6; low altitude sojourn at 520 m, night 1 Change in apnea-/hypopnea index over the course of high altitude exposure during 2 sojourns at 5050 m compared to low altitude
Trial Locations
- Locations (1)
University of Zurich
🇨🇭Zurich, Switzerland
University of Zurich🇨🇭Zurich, Switzerland