Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

Completed

• Conditions: Peripheral Vascular Disease; Chronic Obstructive Pulmonary Disease; Chronic Renal Failure; Chronic Heart Failure; Acute Myocardial Infarction; Diabetes Mellitus; Cerebrovascular Disease

• Registration Number: NCT03037255
• Lead Sponsor: Marlous Hall

Brief Summary

This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

Detailed Description

Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.

Study Timeline

• Study Start: 2003-01
• Primary Completion: 2013-12
• Study First Submitted: 2017-01-24
• Study First Submitted QC: 2017-01-27
• Study First Posted: 2017-01-31
• Study Completion: 2021-01
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-17
• Last Update Posted: 2022-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 693633

Inclusion Criteria

• Patients must be 18 years or older

Exclusion Criteria

• Patients for which mortality data are missing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients who died from any cause by the end of the study censoring period	8.4 years	Death data was obtained from national death records from the Office for National Statistics

Secondary Outcome Measures

Name	Time	Method
Number of patients who received guideline recommended therapy during the study period	Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days	All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed.