Freezing of gait in Parkinson's disease: in search of the underlying mechanism and the application of a new treatment optio
Completed
- Conditions
- Hyperkinetic rigid syndrome1002803710009841
- Registration Number
- NL-OMON33147
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
Parkinson's disease according to the criteria of the UK brain bank criteria.
Exclusion Criteria
- Presence of neurological central nervous system disorders other that idiopathic PD.
- Surgical treatment for idiopathic PD, such as deep brain stimulation
- Dementia (i.e. a score below the cut-off of the Mattis Dementia Rating Scale)
- Other significant co-morbidity
- Contraindications to MRI scanning (see protocol for a specification)
- Contraindications to the adminstration of Methylphenidate (see protocol for a specification)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>First primary outcome: performance of PD patients with FOG on behavioral tasks<br /><br>compared to PD patients without FOG and healthy controls.<br /><br>Second primary outcome: cerebral activation patterns during shifting between<br /><br>response sets in PD patients with FOG, relative to PD patients without FOG and<br /><br>healthy controls.<br /><br>Third primary outcome: change of performance on response shifting task and gait<br /><br>trajectory after administration of MPH in PD patients with FOG, relative to<br /><br>placebo.<br /><br>Fourth primary outcome: cerebral activation change after administration of MPH<br /><br>in PD patients with FOG, relative to placebo. </p><br>
- Secondary Outcome Measures
Name Time Method <p>First secondary outcome is the performance on the motor tasks of all groups,<br /><br>compared to the performance on the cognitive task and dual task.<br /><br>Second secondary outcome is the cerebral activation patterns during shifting<br /><br>between motor tasks in all groups compared to the cerebral activation patterns<br /><br>during shifting between cognitive tasks and during dual tasks.</p><br>