Multi-centre, blinded, randomised, controlled trial comparing different regimens of the antibiotics Doxycycline and Rifampin for treatment of Alzheimer's Disease

McMaster University (Canada)0 sites500 target enrollmentOctober 6, 2006

Overview

Registry

who.int

Start Date

October 6, 2006

End Date

November 30, 2009

Last Updated

5 years ago

Study Type

Interventional

Sex

All

Sponsor

McMaster University (Canada)

•1\. Probable Alzheimer's disease
•2\. Aged 50 \- 99 years old, either sex
•3\. Standardised Mini Mental State Examination (SMMSE) score 14 to 26 inclusive
•4\. Consenting patient (or Power of Attorney \[POA] consents for patient)
•5\. Consenting caregiver
•6\. Sufficient English to complete standardised testing in English
•7\. May reasonably be expected to complete a one year trial

•1\. Other neuro\-degenerative diseases such as Lewy body, Parkinson's, fronto\-temporal, Huntington's Chorea, Down's Syndrome or Creutzfeld Jacob Disease
•2\. Cognitive impairment due to acute cerebral trauma, subdural haematoma, injuries from chronic trauma, hypoxic cerebral damage
•3\. B12 deficiency, cancer or infections e.g. acquired immune deficiency syndrome (AIDS)
•4\. Endocrine deficiencies
•5\. Hypercalcemia, hypothyroidism, hyperparathyroidism, Cushing's syndrome, severe renal failure, poorly controlled diabetes mellitus, pituitary disease, etc.
•6\. Mental retardation
•7\. Significant cerebrovascular disease or multi\-infarct dementia
•8\. Intra\-cranial pathology, tumour or hydrocephalus
•9\. Co\-existing medical conditions such as history of epilepsy or convulsions
•10\. Clinically significant psychiatric conditions or moderate to severe behavioural disturbances