Effect of Resistance Training Variable Manipulation in Postmenopausal Breast Cancer Survivors.

Not Applicable

• Conditions: Postmenopause; Breast Cancer Survivors
• Interventions: Other: Control group; Other: Lower-load resistance training (LL); Other: Higher-volume resistance training (HV); Other: Higher-load resistance training (HL)

• Registration Number: NCT03644329
• Lead Sponsor: Universidade Federal do Triangulo Mineiro

Brief Summary

This study intends to evaluate the impact of resistance training variable manipulation (intensity and volume) on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Detailed Description

The treatment for breast cancer (chemotherapy, radiotherapy and hormone therapy) provokes collateral effects,such as muscle mass and strength losses, increase of fat mass, fatigue and disability and reduced quality of life in postmenopausal breast cancer survivors. The resistance training is assumed as a non-pharmacologic interventions in postmenopausal breast cancer survivors. However, it is unclear whether the manipulation of training variables (intensity and volume) maximize the effects of resistance training on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Study Timeline

• Study Start: 2018-05-13
• Status Verified: 2018-08
• Study First Submitted: 2018-08-14
• Study First Submitted QC: 2018-08-21
• Last Update Submitted: 2018-08-21
• Study First Posted: 2018-08-23
• Last Update Posted: 2018-08-23
• Primary Completion: 2018-11-10
• Study Completion: 2019-12-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• Postmenopausal breast cancer survivors;
• No supervised or unsupervised exercise at least for six months prior to the study.

Exclusion Criteria

• Alcoholics;
• No controlled blood pressure and glucose;
• Presence of myopathies, arthropathies, and neuropathies;
• Presence of muscle, thromboembolic and gastrointestinal disorders, infection diseases.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group, CT	Control group	In the CT, the postmenopausal breast cancer survivers does not perform exercise.
Lower-load resistance training (LL)	Lower-load resistance training (LL)	In the LL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with low loads ( i.e. three sets with 30% of one-repetition maximum).
Higher-volume resistance training (HV)	Higher-volume resistance training (HV)	In the HV, the postmenopause breast cancer survivers will be submitted to 12 weeks of resistance training with high volume ( i.e. six sets with 80% one maximum repetition).
Higher-load resistance training (HL)	Higher-load resistance training (HL)	In the HL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with high loads (i.e. three sets with 80% of one maximum repetition).

Primary Outcome Measures

Name	Time	Method
Evaluation the Fatigability	pre and post intervention (i.e. 12 weeks)	The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree

Secondary Outcome Measures

Name	Time	Method
Four- meter walk test	pre and post intervention (i.e. 12 weeks)	The volunteers will walk 4 meter. The time will be computed to determine the gait velocity (m/s).
Six Minutes-walk test (6MWT)	pre and post intervention (i.e. 12 weeks)	The volunteers will walk 6 minutes. The distance (meters) will be recorded after completes the test. The 6MWT will be performed indoor, on a flat floor in a sports court.
Timed Up and Go test	pre and post intervention (i.e. 12 weeks)	The volunteers will be advised to get up from a chair, walk three meters, turn around, go back to the chair, and sit down. The time (seconds) will be recorded. The test will be performed indoor, on a flat floor in a sports court.
Fat mass	pre intervention and post intervention (i.e. 12 weeks)	The fat mass (kg) will be assessed via dual-energy x-ray absorptiometry scanning (iDXA; GE Healthcare-Luna, Madison, WI; software Encore version 14.10).
10-meter walk test	pre and post intervention (i.e. 12 weeks)	The volunteers will walk 10 meters. The gait speed will be evaluated (m/s). The test will be performed indoor, on a flat floor in a sports court.
400-meter walk test	pre and post intervention (i.e. 12 weeks)	The volunteers will walk 400 meters. The gait speed will be evaluated (m/s). The test will be performed indoor, on a flat floor in a sports court.
900-meter walk test	pre and post intervention (i.e. 12 weeks)	The volunteers will walk 900 meters. The gait speed will be evaluate (m/s). The test will be performed indoor, on a flat floor in a sports court.
Muscle mass	pre and post intervention (i.e. 12 weeks)	The muscle mass (kg) will be assessed via dual-energy x-ray absorptiometry scanning (iDXA; GE Healthcare-Luna, Madison, WI; software Encore version 14.10).
Muscle strength	pre and post intervention (i.e. 12 weeks)	Muscle strength will be evaluated by one repetition maximum (1RM) test.
Five-times-sit-to-stand test	pre and post intervention (i.e. 12 weeks)	The volunteers will rise from a chair and returned to the seated position as quickly as possible for five repetitions. The time will be recorded (seconds).

Trial Locations

Locations (1)

Post-degree program in physical education; 🇧🇷 Uberaba, MG - Minas Gerais, Brazil