Lung Health After Tuberculosis: Clinical and Functional Assessment in Post Pulmonary Tuberculosis Egyptian Patients.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- Post tuberculosis lung functional impairment
研究概览
简要总结
Some of pulmonary tuberculous patients who completed their medication course experience lung function impairment
详细描述
Some of pulmonary tuberculous patients who completed their medication course experience lung function impairment which may influence their quality of life. However, the pattern and nature of post-tuberculosis lung impairment is still not identified. Thus, the aim of this study was to determine the type and degree of lung physiology changes in previously treated tuberculous patients which latter may affect their quality of life; thus helping clinicians for early diagnosis of lung impairment, especially in tuberculous endemic areas.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient completed an outpatient course of standard first line anti-tuberculosis therapy and declared as cured
排除标准
- •Smoker (to avoid spirometry biases).
- •Extrapulmonary tuberculosis cases
- •Multidrug resistant tuberculosis
- •known contraindications to spirometry testing
- •Individuals with chest wall deformities or neuromuscular diseases
- •Patients who failed to achieve acceptability and reproducibility criteria of the spirometry test
- •Defaulter cases or irregular treatment,
- •known coexisting chronic lung disease as history of asthma or interstitial lung diseases
- •A history of illicit drug use
- •Patients with comorbidities: renal and hepatic insufficiency, heart diseases and metabolic disorders.
结局指标
主要结局
Post tuberculosis lung functional impairment
时间窗: 6 months
spirometry abnormality either: restrictive, obstructive, or mixed
Grading of obstruction function:
时间窗: 6 months
grading according to GOLD : mild , moderate , severe , very severe
post tuberculosis persistent clinical symptoms
时间窗: 6 months
either cough , sputum , breathlessness, hemoptysis
次要结局
未报告次要终点
研究者
Nermeen Aly Mahmoud Abdel Aleem
Lecture in Chest and Tuberculosis Department, Faculty of Medicine
Assiut University