Application of Individualized Positive End-expiratory Pressure Using Electrical Impedance Tomography (EIT) in Patients Undergoing Robot Assisted Laparoscopic Prostatectomy : a Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- PaO2/FiO2
研究概览
简要总结
Steep trendelenburg posture or pneumoperitoneum for surgery causes ventilation problems during surgery, so finding a way to overcome is a challenging task for anesthesiologists. In this study, for patients undergoing robot assisted laparoscopic prostatectomy under general anesthesia, anesthesia is going to perform by applying conventional positive end-expiratory pressure (PEEP 5cmH2O) or individually determined positive end-expiratory pressure values for each patient using electrical impedance tomography. We plan to compare intraoperative ventilation through arterial blood gas analysis to find out the way to improve intraoperative ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •20 - 70 years of age who are scheduled for robotic assisted laparoscopic prostatectomy at the Department of Urology, Gangnam Severance Hospital,
- •ASA-PS (American Society of Anesthesiology Body Rating) I-IlI,
- •Patients with a BMI of 35 kg/m2 or less
排除标准
- •Patients with lung disease
- •BMI >35kg/m2
- •Patients for whom positive end-tidal pressure cannot be applied (large bullae, severe cardiac disease)
- •patient refusal
结局指标
主要结局
PaO2/FiO2
时间窗: end of surgery (before extubation)
PaO2/FiO2 is the ratio of arterial oxygen partial pressure (PaO2) to oxygen fraction (FiO2), and is a commonly used indicator for evaluating pulmonary ventilation and diagnosing lung damage. Using this index, it is possible to determine whether oxygen obtained through the lungs is well delivered to the blood or not. It can be easily obtained by arterial blood gas analysis without complicated formulas or graphs.
次要结局
- ROI (region of interests)(15 minutes after intubation, 1 hour after pnemoperitoneum, end of surgery (before extubation))
- inhomogeneity index(15 minutes after intubation, 1 hour after pnemoperitoneum, end of surgery (before extubation))
- total amount of fluid administered during surgery(end or surgery)
- PaO2/FiO2(15 minutes after intubation, 1 hour after pnemoperitoneum)
- total dose of vasopressor administered during surgery(end of surgery)
- length of hospitalization after surgery(1 month after surgery)
研究者
Chul Ho Chang
Professor
Gangnam Severance Hospital