Pesticides and Parkinson´s Disease

Recruiting

• Conditions: Pesticide-Induced Parkinsonism
• Interventions: Other: exposure to pesticides

• Registration Number: NCT06420310
• Lead Sponsor: Hospital Universitario de Burgos

Brief Summary

The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms.

Detailed Description

Within different risk factors, pesticide exposure increases the risk of developing Parkinson's disease (PD) through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunction.We will conduct a cross-sectional prevalence study with cases (exposed to pesticides) and controls (not exposed to pesticides), randomly selecting 130 individuals in each group. Pesticide exposure will be determined through questionnaires.We will study the prevalence of preclinical and prodromal PD based on pesticide exposure, stratified by age and gender in the exposed, and non-exposed groups. Preclinical and prodromal PD will be assessed using: biological biomarkers and prodromal PD signs. Multivariate analyses will be employed to determine the risk of presenting early PD, adjusting for different clinical covariates. The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure.

Study Timeline

• Study Start: 2024-04-01
• Status Verified: 2024-05
• Study First Submitted: 2024-05-14
• Study First Submitted QC: 2024-05-14
• Last Update Submitted: 2024-05-14
• Study First Posted: 2024-05-20
• Last Update Posted: 2024-05-20
• Primary Completion: 2028-09-30
• Study Completion: 2028-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

• Farmers exposed to pesticides for cases
• No work exposure to pesticides for controls

Exclusion Criteria

• Subjects without signed consent form
• Neurological significant conditions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cases	exposure to pesticides	Subjects exposed to pesticides
Controls	exposure to pesticides	Subjects without any exposure to pesticides

Primary Outcome Measures

Name	Time	Method
Prodromal PD	over the last year	Early non motor symptoms

Trial Locations

Locations (1)

Hospital Universitario de Burgos; 🇪🇸 Burgos, Spain