Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Neurological complications
研究概览
简要总结
This study aims to investigate postoperative clinical, cognitive and neurophysiological assessment of patients after open heart surgery among sample of Egyptian patients.
详细描述
Coronary artery bypass grafting (CABAG) is one of the most common major surgical procedures, as more than 800,000 patients worldwide undergo myocardial revascularization procedures every year. Cardiopulmonary bypass (CPB) is an extracorporeal circulation procedure that assists the operation of cardiac and great vessels and is associated with perioperative morbidity and mortality.
Preoperative neurophysiological status as measured by electroencephalogram (EEG) had a specificity of 94.7% and a sensitivity of 76.9% for predicting 1-week postoperative cognitive status and with specificity of 78.3% and a sensitivity of 77.8% for predicting 3-months postoperative cognitive status.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ≥ 60 years.
- •Both sexes.
- •Patients who are scheduled for on-pump open heart surgery either isolated coronary artery bypass grafting (CABG) or combined CABG and valve surgery.
排除标准
- •Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, or Dementia).
- •Patients with metabolic disturbance.
- •Illiterate patient.
- •Patient with sever cognitive impairment on Mini-mental state Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA)
- •Patients who cannot undergo DEEG recordings (eg, uncooperative).
- •Patients with abnormal brain images except for small vessel disease.
结局指标
主要结局
Neurological complications
时间窗: 4 months postoperatively
Neurological complications, including nonconvulsive seizures after open heart surgery, will be recorded.
次要结局
- Electroencephalography (DEEG) monitoring(24 hours postoperatively)
研究者
Osama Allam Ebrahim
Assistant Lecturer of Neuropsychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Ain Shams University