Examining the effect of combined induced diuresis with euvolemic fluid resuscitation on contrast-induced nephropathy

Phase 1

Completed

• Conditions: Contrast-induced nephropathy; Chronic kidney disease; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12618000167268
• Lead Sponsor: A/Prof Margaret Arstall

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-02-02
• Study Completion: 2022-09-20
• Last Update Posted: 8 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 166

Inclusion Criteria

Inclusion criteria for this trial include:
1. All adult patients with advanced stage III, IV or V chronic kidney disease (serum creatinine more than 1.6 mg/dl (145 mmol/L) and eGFR of less than 40ml/min/1.73m2, and/or Mehran's risk score of 6-16) undergoing an elective or urgent, diagnostic or therapeutic radiocontrast procedure will be approached for consent.

Exclusion Criteria

Exclusion criteria for this trial include:
1. Patients with contrast allergy
2. Hypersensitivity to furosemide
3. Patient on maintenance haemodialysis or peritoneal dialysis
4. Radiocontrast procedure conducted within 72 hours
5. Contraindication or failure to pass urinary catheter
6. Patients with fluctuating baseline serum creatinine measurements
7. Patients with acute renal failure
8. Patients requiring emergency angiography procedures (e.g. STEMI cases)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Binary outcome based on the proportion of participants who experienced CIN. CIN is defined as a more than or equal to 25% rise or absolute rise of more than or equal to 44 µmol/L in serum creatinine over the baseline value when measured in the 72 hours (+/- 12 hours) after contrast exposure.[ Serum creatinine will be measured daily for at least three days following the procedure. If there is a rising trend of serum creatinine, then serum creatinine levels will continue to be followed up until the level stabilises or begins to fall. The primary timepoint will be the day 1 measurement.]

Secondary Outcome Measures

Name	Time	Method
ength of hospitalisation (days) assessed by data linkage to medical records and discharge summaries, [ Number of consecutive days spent in hospital or hospital-at-home will be recorded once the participant has been discharged.]