Pain management in osteoarthritis using the centrally acting analgesics duloxetine and pregabalin - Pain management in osteoarthritis using centrally acting analgesics (DUPRO)

St George's University of London0 sites45 target enrollmentAugust 21, 2012

Overview

No summary available.

Registry

who.int

Start Date

August 21, 2012

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional clinical trial of medicinal product

Sponsor

•Participants fulfilling: 1\.the American College of Rheumatology (ACR) criteria for the diagnosis of hand osteoarthritis, 2\.right or left \-handed 3\.male or female 4\.aged 40\-75 5\.On usual care for hand osteoarthritis including paracetamol and/or NSAIDs
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range 35
•F.1\.3 Elderly (\>\=65 years) yes
•F.1\.3\.1 Number of subjects for this age range 10

•1\. other rheumatological diagnosis e.g. rheumatoid arthritis 2\. current or planned pregnancy 3\. contraindications to duloxetine or pregabalin such as MAOI, SSRI, antidepressants, oral contraceptives, St John’s wort 4\. history of depression 5\. concomitant use of opioids including tramadol and pethidine 6\. recent surgery i.e \< 6 weeks prior to participation in the study 7\. recent insertion of surgical implants i.e. less than 6 weeks before participation prior to entry 8\. Previous use of duloxetine and/or pregabalin 9\. uncontrolled hypertension 10\. eGFR \< 60 ml/min 11\. hepatic impairment defined as ALT \> 2\.5 X ULN within 6 weeks of last clinical assessment 12\. ischaemic heart disease 13\. diabetes mellitus 14\. regular use of alcohol or alcohol abuse(maximum limits are 28 units/week for men and 21 units/ week for women) 15\. lactose intolerance