Central Pain Mechanisms in Osteoarthritis: A Longitudinal Cohort
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Osteoarthritis
- Sponsor
- University of Michigan
- Locations
- 1
- Primary Endpoint
- Pain
- Status
- Withdrawn
- Last Updated
- 9 years ago
Overview
Brief Summary
The primary objective of this study is to evaluate the relative efficacy of a centrally-acting analgesic (duloxetine) versus a peripherally acting analgesic (topical diclofenac) for pain and associated symptom management in knee osteoarthritis. Secondary objectives include the determination of which self-report and experimental pain measures best differentiate those who respond better to duloxetine than diclofenac.
Detailed Description
This is a randomized, blinded, crossover, controlled study design comparing duloxetine and topical diclofenac for osteoarthritis pain. The study cohort will be individuals who have a confirmed diagnosis of knee osteoarthritis. Subjects will be randomized only after all entry criteria have been met. These individuals will be evaluated at baseline, and then followed longitudinally following enrollment.
Investigators
Kristine Phillips
Associate Professor
University of Michigan
Eligibility Criteria
Inclusion Criteria
- •Diagnosed with knee osteoarthritis as defined by American College of Rheumatology (ACR) criteria
- •Males and females age greater than 50 years at time of screening
Exclusion Criteria
- •History of chronic kidney disease or moderate to severe hepatic impairment
- •History of anemia
- •Allergy or intolerance of drug intervention
- •Inability to participate in outcome measures
Outcomes
Primary Outcomes
Pain
Time Frame: One month