A Phase 2a Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
- Conditions
- Systemic Lupus ErythematosusActive Refractory Rheumatoid Arthritis
- Interventions
- Registration Number
- NCT06570798
- Lead Sponsor
- Amgen
- Brief Summary
The main objective is to assess the safety and tolerability of inebilizumab in adult participants with active and refractory systemic lupus erythematosus (SLE) with nephritis (Subprotocol A) and to assess the safety and tolerability of subcutaneous (SC) blinatumomab in adult participants with active and refractory (SLE) with nephritis (Subprotocol B) and in adult participants with active refractory rheumatoid arthritis (RA) (Subprotocol C).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 110
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Subprotocol A and B: Diagnosis of SLE and lupus nephritis (LN) according to 2019 European League Against Rheumatism and the American College of Rheumatology (ACR) classification criteria.
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Subprotocol A and B: Participant must be positive for at least one of the following autoantibodies:
- Antinuclear antibodies (ANA) ≥ 1:80
- Anti-double stranded deoxyribonucleic acid (anti-dsDNA) antibodies elevated to above normal range as established by central laboratory (ie, positive results)
- Anti-Smith antibodies elevated to above normal (ie, positive results).
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Subprotocol A and B: SLEDAI-2K ≥ 8.
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Subprotocol A and B: Active, biopsy-proven, proliferative LN demonstrating class III or class IV with or without co-existing features of Class V LN according to 2018 International Society of Nephrology/Renal Pathology Society (ISN/RPS) criteria. Renal biopsy must have been performed within 6 months before enrollment. The local biopsy report will be used. A central review center will confirm the eligibility.
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Subprotocol A and B: Inadequate response, for lack of efficacy or intolerance after 6 months to at least 1 therapy (Subprotocol A) or 2 therapies (Subprotocol B) at the maximally tolerated doses as recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines (KDIGO, 2024). Inadequate response is defined as:
- UPCR ≥ 1.5 mg/mg
- Less than 50% of proteinuria improvement in the past 3 months.
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Subprotocol C: Diagnosis of RA according to the 2010 ACR/ European Alliance of Associations for Rheumatology (EULAR) classification criteria.
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Subprotocol C: Active disease defined as having all the following criteria:
- DAS28-CRP > 3.2 at screening
- at least 6 tender joints at screening
- at least 6 swollen joints at screening
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Subprotocol C: Refractory disease defined as:
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Moderate to severe active disease despite having received treatment with:
- at least 1 conventional synthetic disease-modifying antirheumatic drug (csDMARD), AND
- at least 2 biologic disease-modifying antirheumatic drugs (bDMARDs) of different mechanisms of action OR 1 bDMARD and at least 1 targeted synthetic disease-modifying antirheumatic drugs (tsDMARD).
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Inadequate response or intolerance to csDMARDs, bDMARDs, and tsDMARDs should be defined as:
- Participant having active disease despite a minimum of 12 weeks of treatment with a csDMARD, bDMARD, or tsDMARD.
- Intolerance to treatment as defined by participant having experienced an adverse effect from treatment with a csDMARD, bDMARD, or tsDMARD.
- Subprotocol A and B: Estimated glomerular filtration rate (eGFR) of < 45 mL per minute per 1.73 m^2 of body surface area (calculated using the Modification of Diet in Renal Disease [MDRD] formula, with screening laboratory results for serum creatinine value).
- Subprotocol A and B: Significant likely irreversible organ damage related to SLE (eg, end-stage renal disease [ESRD]).
- Subprotocol A and B: Any acute, severe lupus related flare during screening that needs immediate treatment.
- Subprotocol A and B: A previous kidney transplant or planned transplant within study treatment period.
- Subprotocol A and B: History of or current renal diseases (other than LN) that in the opinion of the investigator could interfere with the LN assessment and confound the disease activity assessment (eg, diabetic nephropathy).
- Subprotocol A and B: Renal biopsy showing pure class V.
- Subprotocol C: Prior history of current inflammatory joint disease other than RA including but not limited to systemic lupus erythematosus, mixed connective tissue disorder, scleroderma, polymyositis, or significant systemic involvement secondary to RA (eg, vasculitis, pulmonary fibrosis, or Felty's syndrome).
- Subprotocol C: Functional Class IV as defined by the ACR classification of functional status in RA.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Subprotocol A: Inebilizumab 3 Doses Inebilizumab Participants will receive 3 doses of inebilizumab administered via an intravenous (IV) infusion. Subprotocol A: Inebilizumab 4 Doses Inebilizumab Participants will receive 4 doses of inebilizumab administered via an IV infusion. Subprotocol B: Blinatumomab Low-dose Blinatumomab Participants will receive blinatumomab low-dose administered via SC injection. Subprotocol B: Blinatumomab Medium-dose Blinatumomab Participants will receive blinatumomab medium-dose administered via SC injection. Subprotocol B: Blinatumomab High-dose Blinatumomab Participants will receive blinatumomab high-dose administered via SC injection. Subprotocol C: Blinatumomab Low-dose Blinatumomab Participants will receive blinatumomab low-dose administered via SC injection. Subprotocol C: Blinatumomab Medium-dose Blinatumomab Participants will receive blinatumomab medium-dose administered via SC injection. Subprotocol C: Blinatumomab High-dose Blinatumomab Participants will receive blinatumomab high-dose administered via SC injection.
- Primary Outcome Measures
Name Time Method Number of Participants Who Experience a Treatment-emergent Adverse Event (TEAE) Day 1 to Week 52 Number of Participants Who Experience a Serious TEAE Day 1 to Week 52
- Secondary Outcome Measures
Name Time Method Subprotocol A and B: Number of Participants With a 24-hour Urine Protein-creatinine Ratio (UPCR) ≤ 0.5 mg/mg Week 12 and Week 24 Subprotocol A: Number of Participants With Anti-inebilizumab Antibody Formation Day 1 to Week 52 Subprotocol C: Percentage of participants achieving Clinical Disease Activity Index (CDAI) ≤ 2.8 Week 12 and Week 26 Subprotocol A and B: Percent Change From Baseline in UPCR Baseline, Week 12 and Week 24 Subprotocol A and B: Number of Participants With Remission in SLE as Defined by Definition of Remission in SLE (DORIS) Week 12 and Week 24 Subprotocol A and B: Number of Participants With a Lupus Low Disease Activity State (LLDAS) Week 12 and Week 24 Subprotocol A and B: Change From Baseline in SLE Activity Index-2000 (SLEDAI-2K) Score Baseline, Week 12 and Week 24 Subprotocol B and C: Cmax of Blinatumomab Day 1 to Week 12 Subprotocol A and B: Percent Change From Baseline in SLEDAI-2K Score Baseline, Week 12 and Week 24 Subprotocol A: Time to Cmax (tmax) of Inebilizumab Day 1 to Week 52 Subprotocol A and B: Change From Baseline in UPCR Baseline, Week 12 and Week 24 Subprotocol A: Maximum Concentration (Cmax) of Inebilizumab Day 1 to Week 52 Subprotocol A: Area Under the Concentration-time Curve (AUC) of Inebilizumab Day 1 to Week 52 Subprotocol C: Percentage of participants achieving Disease Activity Score-28 Joint C-Reactive Protein (DAS28-CRP) < 2.6 Week 12 and Week 26 Subprotocol B and C: tmax of Blinatumomab Day 1 to Week 12 Subprotocol B and C: AUC of Blinatumomab Day 1 to Week 12 Subprotocol B and C: Number of Participants With Anti-blinatumomab Antibody Formation Day 1 to Week 52 Subprotocol C: Percentage of participants achieving Simplified Disease Activity Index (SDAI) ≤ 3.3 Week 12 and Week 26 Subprotocol C: Percentage of participants achieving American College of Rheumatology (ACR)20 response Week 12 and Week 26 Subprotocol C: Percentage of participants achieving ACR50 response Week 12 and Week 26 Subprotocol C: Percentage of participants achieving ACR70 response Week 12 and Week 26
Trial Locations
- Locations (12)
Vitaly Clinical Research
🇺🇸Miami, Florida, United States
Northwell Health
🇺🇸Great Neck, New York, United States
Prolato Clinical Research Center
🇺🇸Houston, Texas, United States
Centre Hospitalier Universitaire de Liege - Sart Tilman
🇧🇪Liege, Belgium
Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot
🇫🇷Lyon Cédex 3, France
Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil
🇫🇷Strasbourg, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
🇫🇷Toulouse Cedex 9, France
Klinikum der LMU Muenchen
🇩🇪Muenchen, Germany
IRCCS Ospedale San Raffaele
🇮🇹Milano, Italy
IRCCS Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
Vida Research Center
🇺🇸Hialeah, Florida, United States
Homestead Associates In Research Inc
🇺🇸Homestead, Florida, United States