NL-OMON54038
招募中
不适用
Microvascular rarefaction in vascular cognitive impairment and heart failure -VCI - CRUCIAL-VCI
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 115 人待定
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- cerebral small vessel disease
- 发起方
- Medisch Universitair Ziekenhuis Maastricht
- 入组人数
- 115
- 状态
- 招募中
- 最后更新
- 去年
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Inclusion criteria for VCI:
- •VCI due to cSVD defined as:
- •o visiting a memory clinic or outpatient clinic Neurology;
- •o cognitive complaints;
- •o demonstration of a cognitive deficit: MoCA less than 26 or impairment in at
- •least 1 cognitive
- •domain in neuropsychological assessment
- •o imaging evidence of cerebral small vessel disease:
- •\- extensive leukoaraiosis on CT, or
- •\- (early) confluent WMH on MRI (Fazekas score \>\= 2\), or
排除标准
- •Exclusion criteria for both VCI and controls
- •Inclusion criteria are not met
- •Unwillingness or inability to give written consent
- •mentally incompetent (or reasonable doubt about competence) to give informed
- •Contraindications to MRI, among which: pacemaker, metallic foreign body,
- •claustrophobia, pregnancy, neurostimulator, other kinds of implanted devices or
- •insulin pump
- •Contraindications to gadolinium contrast agent used for MRI, among which
- •allergy or severe renal impairment (eGFR \<30 ml/min)
- •Other major neurological or psychiatric conditions affecting the brain and
结局指标
主要结局
未指定
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