ACTIB: (Assessing Cognitive behavioural Therapy in Irritable Bowel): a randomised controlled trial of clinical and cost effectiveness of therapist-delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome

niversity of Southampton (UK)0 个研究点目标入组 558 人开始时间: 2013年11月18日最近更新: 2021年7月21日

适应症

试验速览

2015 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/26179651 protocol 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29508539 qualitative study results 2019 Abstract results in https://www.ncbi.nlm.nih.gov/pubmed/31042143 results abstract (added 02/05/2019) 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31492643 results (added 09/09/2019) 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30971419 results (added 27/09/2019) 2019 Results article in http://dx.doi.org/10.1136/gutjnl-2018-317805 RCT results (added 04/11/2019)

•1. Adults (male and female, 18 years and over) with refractory IBS (clinically significant symptoms defined by a IBS-SSS i.e. >75)
•2. Fulfilling ROME III criteria and who have been offered first-line therapies (e.g. anti-spasmodics, anti-depressants or fibre-based medications) but still have continuing IBS symptoms for 12 months or more

•Current exclusion criteria as of 05/12/2013:
•1. Unexplained rectal bleeding or weight loss
•2. Diagnosis of inflammatory bowel disease, coeliac disease, peptic ulcer disease or colorectal carcinoma
•3. Unable to participate in CBT due to speech or language difficulties
•4. No access to an internet computer to be able to undertake the low intensity CBT, previous access to the MIBS website, received CBT for IBS in the last two years
•Previous exclusion criteria:
•1. Unexplained rectal bleeding or weight loss
•2. Diagnosis of inflammatory bowel disease, coeliac disease, peptic ulcer disease or colorectal carcinoma
•3. Unable to participate in CBT due to speech or language difficulties
•4. No access to an internet computer to be able to undertake the low intensity CBT or previous participation in the MIBS study

发起方

niversity of Southampton (UK)