Pharmacodynamics of Injection of Cisatracurium Base on Lean Body Mass Pattern to Maintain Deep Neuromuscular Blockade in Obese Patients
- Conditions
- Obese PatientsLaparoscopic Colorectal Surgery
- Interventions
- Behavioral: base on Lean Body Mass PatternBehavioral: base on Actual Body WeightGenetic: obese patientsGenetic: normal patients
- Registration Number
- NCT05391958
- Lead Sponsor
- The First Hospital of Qinhuangdao
- Brief Summary
To observe the pharmacodynamics of intravenous injection of cisatracurium to maintain deep neuromuscular blockade in obese patients with lean body mass in laparoscopic colorectal surgery
- Detailed Description
According to the random number table method, one hundred and twenty patients who underwent elective laparoscopic colorectal surgery were divided into four groups (n=30): Normal weight patients according to lean body weight group(NL group), normal weight patients according to real weight group (NR group), obese patients according to lean body weight group(OL group), and obese patients according to real weight group(OR group).Intraoperative deep neuromuscular blockade (PTC≤2)was maintained in all four groups.The dosage of cisatracurium, the number of injections,time to effect,time to recovery from TOFr,time to recover TOFr（train-of-four rate） to 0.7 and 0.9,and time to stay in PCAU were recorded.The surgeon's satisfaction with the operative field and the average intraoperative pneumoperitoneum pressure were recorded at the time of pneumoperitoneum establishment,1 hour and 2 hours after pneumoperitoneum establishment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
- Laparoscopic Colorectal Surgery
- American Society of Anesthesiologists (ASA) grades I-III
- Patients with heart, lung and other vital organ disorders
- Preoperative fluid and electrolyte disturbance
- Preoperative water and electrolyte disorders have a history of neuromuscular disease or take medications that have an impact on neuromuscular function
- There is a significant airway difficulty
- Refuse to sign informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Obese Lean group obese patients the medication group was given according to the lean body mass of obese weight patients Normal Lean group normal patients For normal weight patients, the medication group was given according to the lean body mass Obese Real group obese patients the medication group was given according to the actual weight of obese weight patients Normal Lean group base on Lean Body Mass Pattern For normal weight patients, the medication group was given according to the lean body mass Obese Lean group base on Lean Body Mass Pattern the medication group was given according to the lean body mass of obese weight patients Normal Real group normal patients the medication group was given according to the actual weight of normal weight patients Obese Real group base on Actual Body Weight the medication group was given according to the actual weight of obese weight patients Normal Real group base on Actual Body Weight the medication group was given according to the actual weight of normal weight patients
- Primary Outcome Measures
Name Time Method Change in TOF(train of four) recovered to 0.7 and 0.9 from the last injection up to 1 hour after the surgery The recovery of TOF(train of four) was continue observed after surgery.Recording the time both when TOF(train of four) recovered to 0.7 and 0.9
Change in average dosing interval time during the surgery PTC(post-tetanic count)was measured every 6min during the operation, and cisatracurium was injected once when PTC \> 2,average dosing interval time was recorded
Change in Times of adding cisatracurium during the surgery PTC was measured every 6min during the operation, and cisatracurium was injected once when PTC \> 2,and recording the total times of injection.
Change in time of onset through study completion, an average of 3 minute after induction 0.15mg/kg (3ED95) cisatracurium was given to all groups according to actual body weight as induction dose. Tracheal intubation was performed in all groups when TOFr(train of four ratio)=0.recording the time during this process.
Change in total dosage of cisatracurium during the surgery PTC(post-tetanic count) was measured every 6min during the operation, and cisatracurium was injected once when PTC \> 2,and recording the total dosage of total dosage of cisatracurium
Change in time during PACU(postanesthesia care unit) up to 2 hour after the surgery recoding the duration of stay in PACU(postanesthesia care unit)
surgical rating scale(SRS) during the surgery Surgical rating Scale (SRS) was evaluated by surgical surgeons at the beginning, 1h and 2h of surgery, with a range of 1 to 5, corresponding to "extremely poor", "poor", "adequate", "good" and "best".
- Secondary Outcome Measures
Name Time Method Incidence of postoperative pain Immediately after surgery and One day after surgery Incidence of postoperative pain (shoulder, lumbar abdomen, arm)
Whether hypoxemia occurs after extubation within 10 minutes after extubation Observe the occurrence of hypoxemia after extubation
Change in PaCO2 before and after pneumoperitoneum before and after pneumoperitoneum during the surgery arterial blood gas(ABG) was measured before and after pneumoperitoneum.Recording PaCO2 before and after pneumoperitoneum
The change of MAP (mean arterial pressure) immediately , 10 minutes , 20 minutes , 30 minutes and 40 min later after the first injection Mean arterial pressure were recorded immediately , 10 minutes , 20 minutes , 30 minutes , and 40 minutes later after the first injection
The change of HR(heart rate) immediately , 10 minutes , 20 minutes , 30 minutes and 40 min later after the first injection the heart rate were recorded immediately , 10 minutes , 20 minutes , 30 minutes , and 40 minutes later after the first injection
Trial Locations
- Locations (1)
The First hosptial of Qinhuangdao
🇨🇳Qinhuangdao, China