Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.

Completed

• Conditions: HIV Infections; Pregnancy

• Registration Number: NCT00000830
• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Brief Summary

To determine the levels of zidovudine triphosphate ( AZT-TP ) in maternal and fetal cord blood mononuclear cells. To determine the ratio of AZT-TP to endogenous nucleoside triphosphate levels in maternal and fetal cells. To determine the extent of drug transfer through the feto/placental unit.

Detailed Description

Not available

Study Timeline

• Status Verified: 1998-03
• Study First Submitted: 1999-11-02
• Study First Submitted QC: 2001-08-30
• Study First Posted: 2001-08-31
• Last Update Submitted: 2005-06-23
• Last Update Posted: 2005-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (6)

Univ of Medicine & Dentistry of New Jersey / Univ Hosp; 🇺🇸 Newark, New Jersey, United States

Bellevue Hosp / New York Univ Med Ctr; 🇺🇸 New York, New York, United States

Mount Sinai Med Ctr / Pediatrics; 🇺🇸 New York, New York, United States

Regional Med Ctr at Memphis; 🇺🇸 Memphis, Tennessee, United States

Saint Jude Children's Research Hosp of Memphis; 🇺🇸 Memphis, Tennessee, United States

San Juan City Hosp; 🇵🇷 San Juan, Puerto Rico