A Randomized, Controlled Double Blind Acute Study: Effects of Protein Blends on Muscle Protein Synthesis and Breakdown in Healthy Older Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Muscle Synthesis
- Sponsor
- DuPont Nutrition and Health
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Fractional Synthetic Rate (Muscle Protein Synthesis)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.
Investigators
Eligibility Criteria
Inclusion Criteria
- •55-70 yr olds Stable Body weight
Exclusion Criteria
- •Exercise training (\>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
- •Significant heart, liver, kidney, blood, respiratory disease or thyroid issues
- •Peripheral vascular disease
- •Orthopedic injury that prohibits participation in the exercise training
- •Diabetes mellitus or other untreated endocrine disease
- •Active cancer (all groups) and history of cancer
- •Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
- •Neurologic Injury or disease
- •Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
- •Alcohol or drug abuse
Outcomes
Primary Outcomes
Fractional Synthetic Rate (Muscle Protein Synthesis)
Time Frame: baseline, 3 hrs, 5 hrs
The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.
Secondary Outcomes
- Anti-inflammatory and Anti-oxidant Markers(baseline, 3 hrs, 5 hrs)
- Intracellular Signalling Genes and Proteins(baseline, 3 hrs, 5 hrs)