Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults

Not Applicable

Completed

• Conditions: Muscle Synthesis
• Interventions: Dietary Supplement: Soy Dairy Protein Blend; Dietary Supplement: Positive Control (Dairy Whey Protein)

• Registration Number: NCT01847261
• Lead Sponsor: DuPont Nutrition and Health

Brief Summary

During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-04-24
• Study First Submitted QC: 2013-05-01
• Study First Posted: 2013-05-06
• Primary Completion: 2014-11
• Study Completion: 2014-12
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-03
• Last Update Posted: 2019-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

55-70 yr olds Stable Body weight

Exclusion Criteria

1. Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
2. Significant heart, liver, kidney, blood, respiratory disease or thyroid issues
3. Peripheral vascular disease
4. Orthopedic injury that prohibits participation in the exercise training
5. Diabetes mellitus or other untreated endocrine disease
6. Active cancer (all groups) and history of cancer
7. Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
8. Neurologic Injury or disease
9. Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
10. Alcohol or drug abuse
11. Tobacco use (smoking or chewing)
12. Malnutrition (BMI < 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
13. Obesity (BMI > 30 kg/m2)
14. Low hemoglobin levels (below normal values)
15. Food allergies
16. Taking dietary supplements such as green tea, omega 3 fatty acids, etc.
17. Females

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Soy Dairy Protein Blend	Soy Dairy Protein Blend	30 grams of Soy Dairy Protein Blend given as a single beverage following leg resistance exercise
Positive Control (Dairy Whey Protein)	Positive Control (Dairy Whey Protein)	30 grams of Dairy Whey Protein will be given as a single beverage following leg resistance exercise

Primary Outcome Measures

Name	Time	Method
Fractional Synthetic Rate (Muscle Protein Synthesis)	baseline, 3 hrs, 5 hrs	The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.

Secondary Outcome Measures

Name	Time	Method
Anti-inflammatory and Anti-oxidant Markers	baseline, 3 hrs, 5 hrs	Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx).
Intracellular Signalling Genes and Proteins	baseline, 3 hrs, 5 hrs	Phosphorylation of Mammalian Target of Rapamycin (mTOR) pathway will be measured using Western blot techniques

Trial Locations

Locations (1)

University of Texas Medical Branch; 🇺🇸 Galveston, Texas, United States