Effect of CPAP on Postoperative Delirium
- Conditions
- DeliriumSleep Apnea, Obstructive
- Interventions
- Device: CPAP
- Registration Number
- NCT01816685
- Lead Sponsor
- Duke University
- Brief Summary
Patients with a medical condition known as obstructive sleep apnea may be at increased risk of delirium following surgery. This study loans autotitrating CPAP machines to randomly-selected patients who are at high-risk for obstructive sleep apnea with the goal of preventing post-operative delirium.
- Detailed Description
Patients undergoing elective knee and hip replacements will be prospectively enrolled. These surgical procedures all have an expected length of stay \> 3 days. Immediately following enrollment, patients will be randomized to receive CPAP or routine peri-operative care. Patients in the CPAP group will be instructed to wear an autotitrating positive airway pressure (APAP) device any time they sleep prior to surgery and on postoperative days 0, 1, and 2.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 135
- Age 50 and above
- Scheduled for an elective knee or hip replacement
- Ability to speak English and give informed consent
- At risk for obstructive sleep apnea as defined by a STOP-BANG score > 2
- History of psychiatric or neurologic illness that would confound delirium assessment
- Severe tracheal or lung disease
- Contraindications to face-mask CPAP
- Treated OSA
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CPAP CPAP Patients in the CPAP group will be instructed to wear an autotitrating positive airway pressure (APAP) device any time they sleep prior to surgery and on postoperative days 0, 1, and 2.
- Primary Outcome Measures
Name Time Method Presence of Postoperative Delirium Postoperative day 2 Assessments for delirium were made on postoperative day 2 using the Confusion Assessment Method (CAM) Diagnostic Algorithm. This binary tool identifies the presence or absence of delirium
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Duke University
🇺🇸Durham, North Carolina, United States